Table 1 Univariable analysis of prognostic variables related to hospital mortality in 96 patients with cryptococcal meningitis at Emilio Ribas Institute of Infectious Diseases, São Paulo, Brazil
Variables | All | Deaths | Survivors | p* |
|---|---|---|---|---|
Age (years), average (IQR) | 38.7 (29–46) | 44.2 (36–52.5) | 36.4 (28–44.5) | 0.007 |
Glasgow coma scale, average (IQR) | 15 (15–15) | 14 (14–15) | 15 (15–15) |  < 0.001 |
ICU transfer, n (%) | 27/90 (30%) | 15/22 (68.2%) | 12/68 (17.7%) |  < 0.001 |
Signs and symptoms at admission | ||||
 Nausea | 28/90 (31.1%) | 6/22 (27.5%) | 22/68 (32.4%) | 0.07 |
 Seizures | 12/90 (13.3%) | 6/22 (27.5%) | 6/68 (8.8%) | 0.06 |
 Mental confusion | 19/90 (21.1%) | 8/22 (36.4%) | 11/68 (16.2%) | 0.07 |
 Torpor | 4/90 (4.4%) | 3/22 (13.6%) | 1/68 (1.5%) | 0.004 |
Clinical-laboratory data | ||||
 Systemic arterial hypertension | 6/90 (6.7%) | 5/22 (22.7%) | 1/68 (1.5%) | 0.003 |
 Pneumonia | 11/90 (12.2%) | 6/22 (27.3%) | 5/68 (7.4%) | 0.02 |
 Culture of Cryptococcus spp. from extra neural sites | 20/89 (22.5%) | 9/22 (40.9%) | 11/67 (16.4%) | 0.04 |
 Culture of Cryptococcus spp. from bloodstream | 18/89 (20.2%) | 8/22 (36.4%) | 10/67 (14.9%) | 0.06 |
 Culture of Cryptococcus spp. from skin | 3/89 (3.4%) | 2/22 (9.1%) | 1/67 (1.5%) | 0.15 |
 CSF opening pressure (cmH2O)-average (IQR) | 39.4 (22.4–50) | 47.9 (26.2–60.5) | 36.8 (20.5–50) | 0.20 |
 CSF yeasts cout (yeasts/mm3)-average (IQR) | 749 (6–665) | 1696 (340–2240) | 443.2 (3–384) |  < 0.001 |
 Urea level (mg/dL)-average (IQR) | 33.41 (21–40) | 42.9 (22–48) | 30.0 (21–35) | 0.06 |
 Time-kill of 1 mg/L AMB (hours)-average (IQR) | 27.9 (12–48) | 24 (6–24) | 29.8 (12–48) | 0.17 |
Neuroimage-computed tomography | ||||
 Cerebral edema | 4/90 (4.4%) | 3/22 (13.6%) | 1/68 (1.5%) | 0.04 |
 Ventricular dilation | 4/90 (4.4%) | 3/22 (13.6%) | 1/68 (1.5%) | 0.04 |