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Table 1 Characteristics at inclusion and during follow-up (n = 1013)

From: Association of cellular HIV-1 DNA and virological success of antiretroviral treatment in HIV-infected sub-Saharan African adults

Inclusion

 

Age; years, median (IQR)

35 (30–42)

Sex; female, n (%)

808 (79.8)

WHO clinical stage 1 or 2; n (%)

912 (90)

CD4 cells/mm3

 

 Median (IQR)

465 (379–578)

 Categories, n (%)

 

  < 350

197 (19.4)

  350–499

392 (38.7)

  ≥ 500

424 (41.9)

Plasma HIV-1 RNA; log10 copies/ml*

 

 Median (IQR)

4.7 (4.0–5.3)

 Categories; n (%)

 

  < 5

652 (64.6)

  ≥ 5

358 (35.4)

PBMC HIV-1 DNA; log10 copies/106 cells

 

 Median (IQR)

2.9 (2.5–3.2)

 Categories; n (%)

 

  < 3

576 (56.9)

  ≥ 3

437 (43.1)

 1st line ART regimen; n (%)

 

  TDF/FTC plus EFV

700 (69.1)

  TDF/FTC plus LPV/r

235 (23.2)

  TDF/FTC plus AZT

78 (7.7)

Follow-up

 

Duration of follow-up; patient years

2376

Lost to follow-up; n (%)

30 (3.0)

Death; n (%)

21 (2.1)

CD4 count at M30; cells/mm3#

 

 Median (IQR)

717 (548–887)

 Categories; n (%)

 

  < 350

39 (4.6)

  350–499

119 (14.0)

  ≥ 500

693 (81.4)

Plasma HIV-1 RNA at M30; log10 copies/ml¤

 

 Median (IQR)

0 (0–3.49)

 Categories; n (%)

 

  < 100

711 (83.9)

  100–999

29 (3.4)

  1000–9999

42 (5.0)

  10.000–99.999

32 (3.8)

  ≥ 100.000

33 (3.9)

  1. IQR interquartile range; WHO World Health Organization; ART antiretroviral treatment; TDF tenofovir; FTC emtricitabine; AZT azidothymidine; LPV/r lopinavir/ritonavir; DNA desoxyribonucleic acid; RNA ribonucleic acid; n number of patients
  2. *n = 1010 (3 missing values)
  3. ¤n = 847
  4. #n = 851