Table 3 Posterior distribution of parameters obtained using the AM algorithm
From: Estimating tuberculosis drug resistance amplification rates in high-burden settings
DR- TB related parameter | Estimate (median, 50% CI) | |
|---|---|---|
The Philippines | Viet Nam | |
Proportion of previously INH-susceptible individuals that acquire resistance on treatment failure | 0.84 (0.79–0.89) | 0.77 (0.71–0.84) |
Proportion of previously RIF-susceptible individuals that acquire resistance on treatment failure | 0.05 (0.04–0.07) | 0.011 (0.010–0.012) |
Relative fitness of INH-R TB strains | 0.87 (0.83–0.92) | 0.98 (0.95–1.00) |
Relative fitness of RIF-R TB strains | 0.78 (0.74–0.84) | 0.77 (0.73–0.81) |
Relative fitness of MDR-TB strains | 0.67 (0.58–0.71) | 0.64 (0.56–0.75) |
CDR final/maximum value | 0.49 (0.47–0.51) | 0.66 (0.63–0.69) |
Universal parameters | Estimate (median, 50% CI) | |
|---|---|---|
The Philippines | Viet Nam | |
Rate of rapid progression (ε) (year-1) | 0.33 (0.28–0.37) | 0.22 (0.19–0.29) |
Rate of transition towards late latency (κ) (year-1) | 5.49 (4.78–5.95) | 3.62 (3.13–4.92) |
Rate of re-activation (ν) (year-1) | 0.003 (0.002–0.004) | 0.0017 (0.0016–0.0018) |
Relative risk of re-infection after recovery (δ) | 0.74 (0.64–0.86) | 0.64 (0.56–0.81) |