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Table 2 Diagnostic Accuracy of individual Preoperative Tests according to type of PJI

From: The poor accuracy of D-dimer for the diagnosis of prosthetic joint infection but its potential usefulness in early postoperative infections following revision arthroplasty for aseptic loosening

Markers

Specificity (%)

Sensitivity (%)

PPV (%)

NPV (%)

AUC (95% CI)

D-dimer > 1167 ng/mL

 All PJI

75.3 (69–83)

71.8 (58–86)

45.9 (33.3–58.4)

90.4 (81.1–99.7)

0.774 (0.693–0.854)

 Early

75.3 (69–83)

85.7 (60–100)

15.4 (4–26.7)

99 (88–100)

0.863 (0.785–0.942)

 Delayed

75.3 (69–83)

66.6 (36–97)

15 (4–26.7)

97.1 (86.8–100)

0.721 (0.555–0.887)

 Late

75.3 (69–83)

69.5 (51–88)

32.7 (19.5–46.8)

93.7 (83.9–1009

0.767 (0.665–0.87)

CRP > 1 mg/dL

 All PJI

82.1 (76–88)

84.6 (73–96)

56.8 (44–69)

95 (87–100)

0.869 (0.797–0.940)

 Early

82.1 (76–88)

85.7 (60–100)

19.3 (5–33)

99.13 (91–100)

0.828 (0.612–1)

 Delayed

82.1 (76–88)

88.8 (68–100)

24.2 (9.6–38.8)

99.1 (91–100)

0.936 (0.885–0.986)

 Late

82.1 (76–88)

82.6 (67–98)

43.2 (28.5–57.8)

96.6 (88.5–100)

0.863 (0.772–0.953)

ESR > 15 mm/h

 All PJI

72.8 (65–80)

82 (70–94)

45.7 (34–57.4)

93.5 (82.8–100)

0.792 (0.7–0.885)

 Early

72.8 (65–80)

100 (100–100)

15.5 (5–26)

100 (88–100)

0.897 (0.828–0.967)

 Delayed

72.8 (65–80)

88.8 (63–100)

17.3 (6.4–28.3)

99 (87.3–100)

0.866 (0.765–0.968)

 Late

72.8 (65–80)

73.9 (56–92)

30.9 (18.7–43.1)

94.4 (18.7–43.1)

0.767 (0.592–0.871)

  1. PJI, Prosthetic joint infection; PPV, Positive predictive value; NPV, Negative predictive value; AUC, Area under the curve; CI, Confidence interval