The 6-minute walk test predicts mortality in a pulmonary nontuberculous mycobacteria-predominant bronchiectasis cohort

Table 1 Baseline demographic and clinical characteristics of analytic cohort, bronchiectasis natural history study (n = 300)

Characteristic	N (%)
Follow up (years)–median [IQR]	4.1 [2.8–4.6]
Female	217 (72)
Age–median [IQR]	62 [50–69]
Died	21 (7)
Body Mass Index (kg/m)–median [IQR]	21.4 [19.8–24.2]
Fibrocavitary disease	44 (15)
FEV₁% predicted–median [IQR]	72.5 [58–86.2]
DLCO adj% predicted–median [IQR]	64 [53.8–74]
C-reactive protein (mg/L)–median [IQR]	2.1 [0.8–6]
Comorbidities
Asthma	57 (19)
Cystic fibrosis	20 (7)
Chronic obstructive pulmonary disease	12 (4)
Pulmonary hypertension	8 (3)
Primary ciliary dyskinesia	2 (1)
NTM positive since enrollment^b	219 (74)
MAC^c	168 (57)
M. abscessus^d	97 (33)
Other NTM species	65 (22)
NTM positive at study baseline	150 (51)
MAC	96 (64)
M. abscessus	62 (41)
Other NTM species	24 (16)
AFB smear positive at study baseline	49 (17)
Non-NTM organisms at study baseline
Aspergillus	91 (31)
Pseudomonas	53 (18)
Staphylococcus aureus	17 (6)
Stenotrophomonas	18 (6)

Missing data: BMI: n = 5, Fibrocavitary disease: n = 35, FEV₁: n = 12, DLCO: n = 16, C-reactive protein: n = 1, Microbiology: 6 patients without pulmonary cultures taken at NIH (unable to produce sputum after induction, appointment no-show)
IQR interquartile range [25th percentile–75th percentile], BMI body mass index, FEV₁ forced expiratory volume in 1 s, DLCO diffusing capacity of the lungs for carbon monoxide, NTM nontuberculous mycobacteria, MAC Mycobacterium avium complex, AFB Acid-fast bacilli
^aExcludes M. gordonae
^bIncludes: Mycobacterium avium complex, Mycobacterium avium, Mycobacterium intracellulare/chimaera, Mycobacterium chimaera, Mycobacterium intracellulare
^cIncludes: Mycobacterium abscessus, Mycobacterium abscessus group, Mycobacterium massiliense, Mycobacterium chelonae, Mycobacterium chelonae group

ISSN: 1471-2334