Table 1 Characteristics of the included children (N = 225)
Children on label antiretroviral treatment (n) | Children off-label antiretroviral treatment (n) | Total (n) | Total (%) | p value | |||||
|---|---|---|---|---|---|---|---|---|---|
All children | 175 (77.7%) | % on label | % (within category) | 50 (22.2%) | % off label | % (within category) | 225 | 100% | |
Sex | |||||||||
Males | 81 | 46.2% | 77.88% | 23 | 46.0% | 22.12% | 104 | 100% | |
Females | 94 | 53.8% | 77.69% | 27 | 54.0% | 22.31% | 121 | 100% | 0.97 |
Age last controls | |||||||||
< 1 year | 0 | 0.0% | 0.00% | 2 | 4.0% | 100.00% | 2 | 100% | |
1–2 years | 7 | 4.0% | 87.50% | 1 | 2.0% | 12.50% | 8 | 100% | |
3–5 years | 16 | 9.1% | 84.21% | 3 | 6.0% | 15.79% | 19 | 100% | |
6–11 years | 47 | 26.9% | 70.15% | 20 | 40.0% | 29.85% | 67 | 100% | |
≥ 12 years | 105 | 60.0% | 81.40% | 24 | 48.0% | 18.60% | 129 | 100% | |
Median age (months; IQR) | 169.13 (106–204.9) | 137.08 (98.5–181.5) | 159.33 (102.6–201.2) | 0.0519 | |||||
Follow-up | |||||||||
Followed since birth | 52 | 29.8% | 78.79% | 14 | 28.0% | 21.21% | 66 | 100% | 0.814 |
Origin (Child/Mother) | |||||||||
Foreign Country/Missing | 22 | 12.6% | 91.67% | 2 | 4.0% | 8.33% | 24 | 100% | |
Foreign Country/Foreign Country | 54 | 30.9% | 80.60% | 13 | 26.0% | 19.40% | 67 | 100% | |
Italy/Missing | 33 | 18.9% | 80.49% | 8 | 16.0% | 19.51% | 41 | 100% | |
Italy/Foreign Country | 42 | 24.0% | 76.36% | 13 | 26.0% | 23.64% | 55 | 100% | |
Italy/Italy | 24 | 13.8% | 63.16% | 14 | 28.0% | 36.84% | 38 | 100% | |
Age at the beginning of cART | |||||||||
< 1 year | 7 | 4.0% | 58.33% | 5 | 10.0% | 41.67% | 12 | 100% | |
1–2 years | 14 | 8.0% | 56.00% | 11 | 22.0% | 44.00% | 25 | 100% | |
3–5 years | 23 | 13.1% | 82.14% | 5 | 10.0% | 17.86% | 28 | 100% | |
6–11 years | 44 | 25.1% | 72.13% | 17 | 34.0% | 27.87% | 61 | 100% | |
≥ 12 years | 87 | 49.8% | 87.88% | 12 | 24.0% | 12.12% | 99 | 100% | |
Median age (months, IQR) | 135 (65.4–184.27) | 97.63 (17.7- 136.7) | 126.6 (56.3–176.67) | 0.001 | |||||
Number of previous cART regimens | |||||||||
1 regimen | 30 | 17.1% | 66.67% | 15 | 30.0% | 33.33% | 45 | 100% | 0.045 |
2 regimens | 43 | 24.5% | 86.00% | 7 | 14.0% | 14.00% | 50 | 100% | |
3 regimens | 28 | 16.0% | 71.79% | 11 | 22.0% | 28.21% | 39 | 100% | |
4 regimens | 20 | 11.4% | 74.07% | 7 | 14.0% | 25.93% | 27 | 100% | |
5 regimens | 22 | 12.6% | 81.48% | 5 | 10.0% | 18.52% | 27 | 100% | |
6 regimens | 16 | 9.1% | 94.12% | 1 | 2.0% | 5.88% | 17 | 100% | |
7 regimens | 7 | 4.0% | 77.78% | 2 | 4.0% | 22.22% | 9 | 100% | |
8 regimens | 5 | 2.8% | 83.33% | 1 | 2.0% | 16.67% | 6 | 100% | |
9 regimens | 1 | 0.6% | 100.00% | 0 | 0.0% | 0.00% | 1 | 100% | |
10 regimens | 1 | 0.6% | 50.00% | 1 | 2.0% | 50.00% | 2 | 100% | |
11 regimens | 2 | 1.1% | 100.00% | 0 | 0.0% | 0.00% | 2 | 100% | |
Pre-cART VL | |||||||||
Detectable | 52 | 29.8% | 68.42% | 24 | 48.0% | 31.58% | 76 | 100% | 0.021 |
Undetectable | 68 | 38.9% | 83.95% | 13 | 26.0% | 16.05% | 81 | 100% | |
Missing | 55 | 31.4% | 80.88% | 13 | 26.0% | 19.12% | 68 | 100% | |
VL at last check | |||||||||
Detectable | 29 | 16.6% | 74.36% | 10 | 20.0% | 25.64% | 39 | 100% | 0.583 |
Undetectable | 145 | 82.9% | 78.38% | 40 | 80.0% | 21.62% | 185 | 100% | |
Missing | 1 | 0.6% | 100.00% | 0 | 0.0% | 0.00% | 1 | 100% | |
Pre cART CD4+ lymphocytes count | |||||||||
< 15% | 12 | 6.9% | 85.71% | 2 | 4.0% | 14.29% | 14 | 100% | 0.472 |
15–24% | 15 | 8.6% | 75.00% | 5 | 10.0% | 25.00% | 20 | 100% | |
≥ 25% | 91 | 52.0% | 77.78% | 26 | 52.0% | 22.22% | 117 | 100% | |
Missing | 57 | 32.6% | 77.03% | 17 | 34.0% | 22.97% | 74 | 100% | |
CD4+ lymphocytes count at last check | |||||||||
< 15% | 4 | 2.3% | 50.00% | 4 | 8.0% | 50.00% | 8 | 100% | 0.0543 |
15–24% | 15 | 8.6% | 93.75% | 1 | 2.0% | 6.25% | 16 | 100% | |
≥ 25% | 156 | 89.1% | 77.61% | 45 | 90.0% | 22.39% | 201 | 100% | |