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Table 3 Comparisons of discriminating abilities of tested biomarkers presented as areas under the curve (95% CI)

From: Diagnostic and prognostic value of presepsin and procalcitonin in non-infectious organ failure, sepsis, and septic shock: a prospective observational study according to the Sepsis-3 definitions

Tested biomarker AUC (95% CI) p value Cut-off value Sensitivity, (%) Specificity, (%)
Presepsin
 Sepsis vs. non-infectious organ failure 0.877 (0.841–0.906) < 0.001 582 (pg/mL) 70.1 89.4
 Septic shock vs. sepsis 0.618 (0.558–0.675) < 0.001 1285 (pg/mL) 50.4 76.6
Procalcitonin
 Sepsis vs. non-infectious organ failure 0.908 (0.877–0.934) < 0.001 0.51 (ng/mL) 75.5 93.0
 Septic shock vs. sepsis 0.678 (0.619–0.732) < 0.001 2.81 (ng/mL) 59.1 70.9
CRP
 Sepsis vs. non-infectious organ failure 0.858 (0.821–0.890) < 0.001 3.53 (mg/L) 77.0 85.2
 Septic shock vs. sepsis 0.559 (0.498–0.618) 0.088 6.62 (mg/L) 65.7 46.8
  1. AUC area under the curve, CRP C-reactive protein