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Table 2 Clinical course and outcomes for GBS IE cases and controls

From: Streptococcus agalactiae infective endocarditis in Canada: a multicenter retrospective nested case control analysis

 

Cases

(N = 28)

Controls

(N = 84)

(Pearson 2-sided

Chi-square, or 2-tailed t test)

Mean days of symptoms

 Before diagnosis

4.9 ± 5.9

4.2 ± 7.2

P = 0.64

Mean time to culture

 Positivity (hours)

11.8 ± 6.2

15.5 ± 13.2

P = 0.17

Mean number of positive

 Blood culture sets

2.9 ± 2.6

1.7 ± 0.7

P < 0.001

Mean number of blood

 Culture sets collected

2.5 ± 0.5

2.1 ± 0.4

P = 0.048

Community acquired

28 (100%)

79 (94.0%)

P = 0.19

Concurrent skin or soft tissue infection

8 (28.6%)

34 (40.5%)

P = 0.26

Concurrent bone or joint infection

6 (21.4%)

15 (17.9%)

P = 0.68

Recurrent bacteremia

4 (14.3%)

0

P < 0.001

Source identified

14 (50.0%)

65 (77.0%)

P = 0.006

Recent procedure*

3 (10.7%)

3 (3.6%)

P = 0.15

Indwelling line

1 (3.6%)

3 (3.6%)

P = 0.96

Echo done

24 (85.7%)

38 (45.2%)

P < 0.001

ID consult

21 (75.0%)

27 (32.1%)

P < 0.001

Outcomes

   

 In hospital mortality

8 (28.6%)

3 (3.6%)

P < 0.001

 Mean duration of antibiotics (days)

45.1 ± 40.4

19.9 ± 15.7

P < 0.001

  1. *Any surgeries, invasive procedures in past 3 months, including PICC/central line insertion, endoscopy, suprapubic catheter insertion, C-section, therapeutic abortion