Table 1 Epidemiological and clinical characteristics and outcomes of community-acquired urinary tract infection in older patients according to multidrug-resistant or non-multidrug-resistant bacteria
Total cases n 348 | MDR bacteria n 144 | Non-MDR bacteria n 204 | p | |
|---|---|---|---|---|
Male sex, n (%) | 179 (51.4) | 82 (56.9) | 97 (47.5) | 0.102 |
Age (years), median [IQR] | 81 [75–87] | 80 [75–88] | 81 [75–87] | 0.719 |
Age ≥ 75 years, n (%) | 274 (78.7) | 111 (77.1) | 163 (79.9) | 0.595 |
McCabe ≥ 2, n (%) | 268 (77) | 113 (78.5) | 155 (75.9) | 0.607 |
Comorbidites | ||||
Dementia, n (%) | 104 (29.9) | 52 (36.1) | 52 (25.5) | 0.043 |
Diabetes mellitus, n (%) | 130 (37.4) | 56 (38.9) | 74 (36.3) | 0.653 |
COPD, n (%) | 51 (14.7) | 20 (13.9) | 31 (15.2) | 0.761 |
CKD, n (%) | 113 (32.5) | 44 (30.6) | 69 (33.8) | 0.562 |
Cancer, n (%) | 77 (22.1) | 30 (20.8) | 47 (23) | 0.695 |
Indwelling urinary catheter, n (%) | 81 (23.3) | 40 (27.8) | 41 (20.1) | 0.122 |
HCA-UTI, n (%) | 214 (61.5) | 110 (76.4) | 104 (50.9) | < 0.001 |
Previous hospitalization, n (%) | 128 (36.8) | 67 (46.5) | 61 (29.9) | 0.002 |
Previous antimicrobial therapy, n (%) | 182 (52.3) | 94 (65.3) | 88 (43.1) | < 0.001 |
Nursing home residence, n (%) | 28 (8) | 20 (13.9) | 8 (3.9) | 0.001 |
Clinical characteristics | ||||
APACHE II, median [IQR] | 12 [9–17] | 13 [9–17] | 12 [9–17] | 0.981 |
Fever, n (%) | 239 (68.7) | 98 (68.1) | 141 (69.1) | 0.907 |
RR ≥ 22, n (%) | 71 (20.4) | 23 (15.9) | 48 (23.5) | 0.105 |
Altered mental status, n (%) | 158 (45.4) | 76 (52.8) | 82 (40.2) | 0.021 |
SBP < 100, n (%) | 62 (17.8) | 30 (20.8) | 32 (15.7) | 0.255 |
qSOFA ≥ 2, n (%) | 90 (25.9) | 40 (27.8) | 50 (24.5) | 0.535 |
Sepsis (SOFA ≥ 2), n (%) | 184 (52.9) | 78 (54.1) | 106 (51.9) | 0.744 |
Septic shock-3, n (%) | 56 (16) | 25 (17.4) | 31 (15.2) | 0.657 |
Albumin, median [IQR] | 3.1 [2.8–3.5] | 3.0 [2.7–3.5] | 3.2 [2.9–3.5] | 0.063 |
Leukocytosis, median [IQR] | 13,200 [9400–18575] | 12,800 [9025–18425] | 13,500 [9750–18600] | 0.170 |
Polymicrobial UTI, n (%) | 36 (10.3) | 21 (14.6) | 15 (7.4) | 0.033 |
Bacteremia, positive/total blood cultures (%) | 84/209 (40.2) | 35/85 (41.2) | 49/124 (39.5) | 0.951 |
IEAT, n (%) | 81 (23.3) | 48 (33.3) | 33 (16.2) | < 0.001 |
Outcomes | ||||
In-hospital mortality, n (%) | 30 (8.6) | 11 (7.6) | 19 (9.3) | 0.699 |
30-day mortality, n (%) | 44 (12.6) | 20 (13.9) | 24 (11.8) | 0.624 |
Length of hospital stay (days), median [IQR] | 5 [4–8] | 6 [4–8] | 5 [4–7] | 0.029 |