Table 3 Baseline clinical and laboratory features

Number randomized

55

50

105

Body mass index (BMI) in kgs/m^{2 a}

 Number of observations

55

49

104

 Mean (standard deviation)

30.8 (7.5)

31.3 (7.3)

31.0 (7.4)

 BMI categories

  < 18.5

1 (1.8)

1 (2.0)

2 (1.9)

  18.5 to < 25 (normal)

13 (23.6)

9 (18.4)

22 (21.2)

  25 to < 30 (over-weight)

14 (25.5)

12 (24.5)

26 (25.0)

  ≥ 30 (obese)

27 (49.1)

27 (55.1)

54 (51.9)

ECG QTc interval (ms)

 Overall–mean (SD)

417 (22)

409 (20)

413 (22)

 Males–mean(SD)

410 (22)

404 (19)

407 (21)

 Females–mean(SD)

430 (15)

423 (16)

427 (16)

Serum Potassium (mmols/L)

 Number of observations

52

41

93

 Mean (SD)

4.6 (0.9)

4.6 (0.7)

4.6 (0.8)

Visual color test, (%)

 Normal

54 (94.7)

50 (100.0)

104 (97.2)

 Abnormal

3 (5.3)

0

3 (2.8)

Pulse rate (beats/min), median (IQR)

78 (70–86)

78 (67–85)

78 (68–86)

Visual acuity–left eye, n (%)

 6/6

42 (76.4)

37 (77.1)

79 (76.7)

 5/6

4 (7.3)

1 (2.1)

5 (4.9)

 4/6

2 (3.6)

0

2 (1.9)

 20/30

6 (10.9)

8 (16.7)

14 (13.6)

 6/12

1 (1.8)

1 (2.1)

2 (1.9)

 6/18

0

1 (2.1)

1 (1.0)

Visual acuity–right eye, n (%)

 6/6

43 (75.4)

38 (82.6)

81 (78.6)

 5/6

5 (8.8)

0

5 4.9)

 4/6

2 (3.5)

1 (2.2)

3 (2.9)

 6/12

0

1 (2.2)

1 (1.0)

 20/30

7 (12.3)

6 (13.0)

13 (12.6)