Table 7 Appropriateness of antibiotic prescription for targeted therapy of IPD from different regions of China
|  | All Patients n = 806 | North n = 368 | East n = 161 | South n = 237 | Northwest n = 40 | p* |
|---|---|---|---|---|---|---|
Penicillins monotherapy | 54 (6.7) | 20 (5.4) | 20 (12.4) | 13 (5.5) | 1 (2.5) | 0.019 |
Cephalosporin monotherapy | 259 (32.1) | 96 (26.1) | 44 (27.3) | 102 (43.0) | 17 (42.5) | 0.000 |
Carbapenem monotherapy | 62 (7.7) | 24 (6.5) | 16 (9.9) | 19 (8.0) | 3 (7.5) | 0.607 |
Cephalosporin plus vancomycin | 134 (16.6) | 72 (19.6) | 20 (12.4) | 33 (13.9) | 9 (22.5) | 0.086 |
Carbapenem plus vancomycin | 140 (17.4) | 51 (13.9) | 49 (30.4) | 31 (13.1) | 9 (22.5) | 0.000 |
Cephalosporin plus linezolid | 54 (6.7) | 38 (10.3) | 1 (0.6) | 15 (6.3) | 0 (0) | 0.000 |
Carbapenem plus linezolid | 33 (4.1) | 15 (4.1) | 3 (1.9) | 14 (5.9) | 1 (2.5) | 0.204 |
Vancomycin plus rifampin | 16 (2.0) | 13 (3.5) | 1 (0.6) | 2 (0.8) | 0 (0) | 0.038 |
Vancomycin monotherapy | 18 (2.2) | 9 (2.4) | 3 (1.9) | 6 (2.5) | 0 (0) | 0.556 |
Linezolid monotherapy | 19 (2.4) | 17 (4.6) | 1 (0.6) | 1 (0.4) | 0 (0) | 0.001 |
Other prescriptions | 17 (2.1) | 13a (3.5) | 3b (1.9) | 1c (0.4) | 0 (0) | – |
Inappropriate use of | Â | Â | Â | Â | Â | Â |
 Carbapenems | 232 (28.8) | 90 (24.5) | 68 (42.2) | 62 (26.2) | 12 (30.0) | 0.000 |
 Vancomycin | 169 (21.0) | 73 (19.8) | 51 (31.7) | 40 (16.9) | 5 (12.5) | 0.001 |
 Linezolid | 62 (7.7) | 41 (11.1) | 3 (1.9) | 17 (7.2) | 1 (2.5) | 0.000 |
No. patients with inappropriate antibiotic use | 361 (44.8) | 169 (45.9) | 88 (54.7) | 90 (38.0) | 14 (35.0) | 0.006 |