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Table 7 Appropriateness of antibiotic prescription for targeted therapy of IPD from different regions of China

From: Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study

 

All Patients

n = 806

North

n = 368

East

n = 161

South

n = 237

Northwest

n = 40

p*

Penicillins monotherapy

54 (6.7)

20 (5.4)

20 (12.4)

13 (5.5)

1 (2.5)

0.019

Cephalosporin monotherapy

259 (32.1)

96 (26.1)

44 (27.3)

102 (43.0)

17 (42.5)

0.000

Carbapenem monotherapy

62 (7.7)

24 (6.5)

16 (9.9)

19 (8.0)

3 (7.5)

0.607

Cephalosporin plus vancomycin

134 (16.6)

72 (19.6)

20 (12.4)

33 (13.9)

9 (22.5)

0.086

Carbapenem plus vancomycin

140 (17.4)

51 (13.9)

49 (30.4)

31 (13.1)

9 (22.5)

0.000

Cephalosporin plus linezolid

54 (6.7)

38 (10.3)

1 (0.6)

15 (6.3)

0 (0)

0.000

Carbapenem plus linezolid

33 (4.1)

15 (4.1)

3 (1.9)

14 (5.9)

1 (2.5)

0.204

Vancomycin plus rifampin

16 (2.0)

13 (3.5)

1 (0.6)

2 (0.8)

0 (0)

0.038

Vancomycin monotherapy

18 (2.2)

9 (2.4)

3 (1.9)

6 (2.5)

0 (0)

0.556

Linezolid monotherapy

19 (2.4)

17 (4.6)

1 (0.6)

1 (0.4)

0 (0)

0.001

Other prescriptions

17 (2.1)

13a (3.5)

3b (1.9)

1c (0.4)

0 (0)

Inappropriate use of

      

 Carbapenems

232 (28.8)

90 (24.5)

68 (42.2)

62 (26.2)

12 (30.0)

0.000

 Vancomycin

169 (21.0)

73 (19.8)

51 (31.7)

40 (16.9)

5 (12.5)

0.001

 Linezolid

62 (7.7)

41 (11.1)

3 (1.9)

17 (7.2)

1 (2.5)

0.000

No. patients with inappropriate antibiotic use

361 (44.8)

169 (45.9)

88 (54.7)

90 (38.0)

14 (35.0)

0.006

  1. a2 patients with cephalosporin plus vancomycin and rifampin, 2 patients with cephalosporin plus linezolid and rifampin, 2 patients with linezolid plus rifampin, 2 patients with carbapenem plus vancomycin and rifampin, 2 patients with teicoplanin monotherapy, 1 patient with carbapenem plus linezolid and rifampin, 1 patient with penicillins plus linezolid and 1 patient with Cephalosporin plus teicoplanin
  2. b3 patients with penicillins plus vancomycin,
  3. c1 patient with penicillins plus linezolid
  4. *All the four regions were compared