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Table 7 Appropriateness of antibiotic prescription for targeted therapy of IPD from different regions of China

From: Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study

  All Patients
n = 806
North
n = 368
East
n = 161
South
n = 237
Northwest
n = 40
p*
Penicillins monotherapy 54 (6.7) 20 (5.4) 20 (12.4) 13 (5.5) 1 (2.5) 0.019
Cephalosporin monotherapy 259 (32.1) 96 (26.1) 44 (27.3) 102 (43.0) 17 (42.5) 0.000
Carbapenem monotherapy 62 (7.7) 24 (6.5) 16 (9.9) 19 (8.0) 3 (7.5) 0.607
Cephalosporin plus vancomycin 134 (16.6) 72 (19.6) 20 (12.4) 33 (13.9) 9 (22.5) 0.086
Carbapenem plus vancomycin 140 (17.4) 51 (13.9) 49 (30.4) 31 (13.1) 9 (22.5) 0.000
Cephalosporin plus linezolid 54 (6.7) 38 (10.3) 1 (0.6) 15 (6.3) 0 (0) 0.000
Carbapenem plus linezolid 33 (4.1) 15 (4.1) 3 (1.9) 14 (5.9) 1 (2.5) 0.204
Vancomycin plus rifampin 16 (2.0) 13 (3.5) 1 (0.6) 2 (0.8) 0 (0) 0.038
Vancomycin monotherapy 18 (2.2) 9 (2.4) 3 (1.9) 6 (2.5) 0 (0) 0.556
Linezolid monotherapy 19 (2.4) 17 (4.6) 1 (0.6) 1 (0.4) 0 (0) 0.001
Other prescriptions 17 (2.1) 13a (3.5) 3b (1.9) 1c (0.4) 0 (0)
Inappropriate use of       
 Carbapenems 232 (28.8) 90 (24.5) 68 (42.2) 62 (26.2) 12 (30.0) 0.000
 Vancomycin 169 (21.0) 73 (19.8) 51 (31.7) 40 (16.9) 5 (12.5) 0.001
 Linezolid 62 (7.7) 41 (11.1) 3 (1.9) 17 (7.2) 1 (2.5) 0.000
No. patients with inappropriate antibiotic use 361 (44.8) 169 (45.9) 88 (54.7) 90 (38.0) 14 (35.0) 0.006
  1. a2 patients with cephalosporin plus vancomycin and rifampin, 2 patients with cephalosporin plus linezolid and rifampin, 2 patients with linezolid plus rifampin, 2 patients with carbapenem plus vancomycin and rifampin, 2 patients with teicoplanin monotherapy, 1 patient with carbapenem plus linezolid and rifampin, 1 patient with penicillins plus linezolid and 1 patient with Cephalosporin plus teicoplanin
  2. b3 patients with penicillins plus vancomycin,
  3. c1 patient with penicillins plus linezolid
  4. *All the four regions were compared