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Table 4 Appropriateness of antibiotic prescription for targeted therapy of non-meningitis IPD

From: Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study

Definitive antibiotics therapy All patients
n = 492
Spn susceptible to penicillin
n = 291
Spn not susceptible to penicillin
n = 201
p
    Susceptible to cefotaxime
n = 99
Not susceptible to cefotaxime
n = 102
Subtotal
n = 201
 
Penicillins monotherapy 54 (11.0) 29 (10.0) 12 (12.1) 13 (12.7) 25 (12.4) 0.389
Cephalosporin monotherapy 220 (44.7) 155 (53.3) 47 (47.5) 18 (17.6) 65 (32.3) 0.000
Carbapenem monotherapy 47 (9.6) 36 (12.4) 5 (5.1) 6 (2.0) 11 (5.5) 0.011
Cephalosporin plus vancomycin 46(9.3) 17 (5.8) 8 (8.1) 21 (20.6) 29 (14.4) 0.001
Carbapenem plus vancomycin 46 (9.3) 20 (6.9) 12 (12.1) 14 (13.7) 26 (12.9) 0.023
Cephalosporin plus linezolid 28 (5.7) 13 (4.5) 3 (3.0) 12 (11.8) 15 (7.5) 0.159
Carbapenem plus linezolid 12 (2.4) 5 (1.7) 5 (5.1) 2 (2.0) 7 (3.5) 0.342
Vancomycin monotherapy 18 (3.7) 5 (1.7) 5 (5.1) 8 (7.8) 13 (6.5) 0.006
Linezolid monotherapy 13 (2.6) 5 (1.7) 2 (2.0) 6 (5.9) 8 (4.0) 0.124
Other prescriptions 8 (1.6) 6a (2.1) 0 (0) 2b (2.0) 2 (1.0)
Inappropriate use of       
 Carbapenems 99 (20.1) 61 (21.0) 22 (22.2) 16 (15.7) 38 (18.9) 0.576
 Vancomycin 70 (14.2) 45 (15.5) 25 (25.3) 0 (0) 25 (12.4) 0.345
 Linezolid 34 (6.9) 24 (8.2) 10 (10.1) 0 (0) 10 (5.0) 0.160
No. patients with inappropriate antibiotic use 161 (32.7) 105 (36.1) 40 (40.4) 16 (15.7) 56 (27.9) 0.056
  1. Spn, Streptococcus pneumoniae
  2. a2 patients with penicillins plus vancomycin, 1 patient with penicillins plus linezolid, 1 patient with Cephalosporin plus teicoplanin and 1 patient with teicoplanin monotherapy
  3. b1 patient with penicillins plus linezolid and 1 patient with teicoplanin monotherapy