Table 4 Appropriateness of antibiotic prescription for targeted therapy of non-meningitis IPD
Definitive antibiotics therapy | All patients n = 492 | Spn susceptible to penicillin n = 291 | Spn not susceptible to penicillin n = 201 | p | ||
|---|---|---|---|---|---|---|
|  |  |  | Susceptible to cefotaxime n = 99 | Not susceptible to cefotaxime n = 102 | Subtotal n = 201 |  |
Penicillins monotherapy | 54 (11.0) | 29 (10.0) | 12 (12.1) | 13 (12.7) | 25 (12.4) | 0.389 |
Cephalosporin monotherapy | 220 (44.7) | 155 (53.3) | 47 (47.5) | 18 (17.6) | 65 (32.3) | 0.000 |
Carbapenem monotherapy | 47 (9.6) | 36 (12.4) | 5 (5.1) | 6 (2.0) | 11 (5.5) | 0.011 |
Cephalosporin plus vancomycin | 46(9.3) | 17 (5.8) | 8 (8.1) | 21 (20.6) | 29 (14.4) | 0.001 |
Carbapenem plus vancomycin | 46 (9.3) | 20 (6.9) | 12 (12.1) | 14 (13.7) | 26 (12.9) | 0.023 |
Cephalosporin plus linezolid | 28 (5.7) | 13 (4.5) | 3 (3.0) | 12 (11.8) | 15 (7.5) | 0.159 |
Carbapenem plus linezolid | 12 (2.4) | 5 (1.7) | 5 (5.1) | 2 (2.0) | 7 (3.5) | 0.342 |
Vancomycin monotherapy | 18 (3.7) | 5 (1.7) | 5 (5.1) | 8 (7.8) | 13 (6.5) | 0.006 |
Linezolid monotherapy | 13 (2.6) | 5 (1.7) | 2 (2.0) | 6 (5.9) | 8 (4.0) | 0.124 |
Other prescriptions | 8 (1.6) | 6a (2.1) | 0 (0) | 2b (2.0) | 2 (1.0) | – |
Inappropriate use of | Â | Â | Â | Â | Â | Â |
 Carbapenems | 99 (20.1) | 61 (21.0) | 22 (22.2) | 16 (15.7) | 38 (18.9) | 0.576 |
 Vancomycin | 70 (14.2) | 45 (15.5) | 25 (25.3) | 0 (0) | 25 (12.4) | 0.345 |
 Linezolid | 34 (6.9) | 24 (8.2) | 10 (10.1) | 0 (0) | 10 (5.0) | 0.160 |
No. patients with inappropriate antibiotic use | 161 (32.7) | 105 (36.1) | 40 (40.4) | 16 (15.7) | 56 (27.9) | 0.056 |