Skip to main content

Table 4 Appropriateness of antibiotic prescription for targeted therapy of non-meningitis IPD

From: Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study

Definitive antibiotics therapy

All patients

n = 492

Spn susceptible to penicillin

n = 291

Spn not susceptible to penicillin

n = 201

p

   

Susceptible to cefotaxime

n = 99

Not susceptible to cefotaxime

n = 102

Subtotal

n = 201

 

Penicillins monotherapy

54 (11.0)

29 (10.0)

12 (12.1)

13 (12.7)

25 (12.4)

0.389

Cephalosporin monotherapy

220 (44.7)

155 (53.3)

47 (47.5)

18 (17.6)

65 (32.3)

0.000

Carbapenem monotherapy

47 (9.6)

36 (12.4)

5 (5.1)

6 (2.0)

11 (5.5)

0.011

Cephalosporin plus vancomycin

46(9.3)

17 (5.8)

8 (8.1)

21 (20.6)

29 (14.4)

0.001

Carbapenem plus vancomycin

46 (9.3)

20 (6.9)

12 (12.1)

14 (13.7)

26 (12.9)

0.023

Cephalosporin plus linezolid

28 (5.7)

13 (4.5)

3 (3.0)

12 (11.8)

15 (7.5)

0.159

Carbapenem plus linezolid

12 (2.4)

5 (1.7)

5 (5.1)

2 (2.0)

7 (3.5)

0.342

Vancomycin monotherapy

18 (3.7)

5 (1.7)

5 (5.1)

8 (7.8)

13 (6.5)

0.006

Linezolid monotherapy

13 (2.6)

5 (1.7)

2 (2.0)

6 (5.9)

8 (4.0)

0.124

Other prescriptions

8 (1.6)

6a (2.1)

0 (0)

2b (2.0)

2 (1.0)

Inappropriate use of

      

 Carbapenems

99 (20.1)

61 (21.0)

22 (22.2)

16 (15.7)

38 (18.9)

0.576

 Vancomycin

70 (14.2)

45 (15.5)

25 (25.3)

0 (0)

25 (12.4)

0.345

 Linezolid

34 (6.9)

24 (8.2)

10 (10.1)

0 (0)

10 (5.0)

0.160

No. patients with inappropriate antibiotic use

161 (32.7)

105 (36.1)

40 (40.4)

16 (15.7)

56 (27.9)

0.056

  1. Spn, Streptococcus pneumoniae
  2. a2 patients with penicillins plus vancomycin, 1 patient with penicillins plus linezolid, 1 patient with Cephalosporin plus teicoplanin and 1 patient with teicoplanin monotherapy
  3. b1 patient with penicillins plus linezolid and 1 patient with teicoplanin monotherapy