Table 2 Risk factors for NTM-PD patients and matched controls
From: Non-tuberculous mycobacterial pulmonary diseases in France: an 8 years nationwide study
Cases n (%) | Controls n (%) | p-value cases/controls | Treated NTM-PD n (%) | Untreated NTM-PD n (%) | p-value treated/not treated | |
|---|---|---|---|---|---|---|
Incident population | 4447 (25.0) | 13,341 (75.0) | 1433 (25.5) | 4195 (74.5) | ||
Charlson comorbidity index score (SD) | 1.6 (2.5) | 0.2 (0.9) | < 0.0001 | 1.7 (2.7) | 1.5 (2.4) | 0.2907 |
Risk factors before NTM-PD diagnosis | ||||||
Chronic lower respiratory diseases | 1529 (34.4) | 359 (2.7) | < 0.0001 | 428 (29.9) | 1,547 (36.9) | < 0.0001 |
COPD (J44) | 836 (18.8) | 168 (1.3) | < 0.0001 | 203 (14.2) | 887 (21.1) | < 0.0001 |
Bronchiectasis (J47) | 472 (10.6) | 16 (0.1) | < 0.0001 | 123 (8.6) | 486 (11.6) | 0.0016 |
Other lower respiratory Chronic diseases | 927 (20.8) | 245 (1.8) | < 0.0001 | 277 (19.3) | 911 (21.7) | 0.0560 |
HIV infection | 389 (8.7) | 30 (0.2) | < 0.0001 | 212 (14.8) | 211 (5.0) | < 0.0001 |
Lung cancer and lung graft | 252 (5.7) | 55 (0.4) | < 0.0001 | 52 (3.6) | 272 (6.5) | < 0.0001 |
Bone marrow transplant | 60 (1.3) | 3 (0.0) | < 0.0001 | 17 (1.2) | 49 (1.2) | 0.9558 |
Gastro-esophageal reflux disease | 131 (2.9) | 120 (0.9) | < 0.0001 | 44 (3.1) | 121 (2.9) | 0.7184 |
Smoking | 164 (3.7) | 112 (0.8) | < 0.0001 | 52 (3.6) | 146 (3.5) | 0.7923 |
Other infectious pneumonia | 1085 (24.4) | 184 (1.4) | < 0.0001 | 286 (20.0) | 1107 (26.4) | < 0.0001 |
Tuberculosis | 628 (14.1) | 14 (0.1) | < 0.0001 | |||
Malnutrition | 978 (22.0) | 261 (2.0) | < 0.0001 | |||
Corticoids | 2550 (57.3) | 4504 (33.8) | < 0.0001 | |||
Cystic fibrosis | 143 (3.2) | 1 (0.0) | < 0.0001 | |||