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Table 2 Risk factors for NTM-PD patients and matched controls

From: Non-tuberculous mycobacterial pulmonary diseases in France: an 8 years nationwide study

  Cases n (%) Controls n (%) p-value cases/controls Treated NTM-PD n (%) Untreated NTM-PD n (%) p-value treated/not treated
Incident population 4447 (25.0) 13,341 (75.0)   1433 (25.5) 4195 (74.5)  
Charlson comorbidity index score (SD) 1.6 (2.5) 0.2 (0.9) < 0.0001 1.7 (2.7) 1.5 (2.4) 0.2907
Risk factors before NTM-PD diagnosis
 Chronic lower respiratory diseases 1529 (34.4) 359 (2.7) < 0.0001 428 (29.9) 1,547 (36.9)  < 0.0001
  COPD (J44) 836 (18.8) 168 (1.3) < 0.0001 203 (14.2) 887 (21.1)  < 0.0001
  Bronchiectasis (J47) 472 (10.6) 16 (0.1) < 0.0001 123 (8.6) 486 (11.6) 0.0016
  Other lower respiratory Chronic diseases 927 (20.8) 245 (1.8) < 0.0001 277 (19.3) 911 (21.7) 0.0560
 HIV infection 389 (8.7) 30 (0.2) < 0.0001 212 (14.8) 211 (5.0) < 0.0001
 Lung cancer and lung graft 252 (5.7) 55 (0.4) < 0.0001 52 (3.6) 272 (6.5) < 0.0001
 Bone marrow transplant 60 (1.3) 3 (0.0) < 0.0001 17 (1.2) 49 (1.2) 0.9558
 Gastro-esophageal reflux disease 131 (2.9) 120 (0.9) < 0.0001 44 (3.1) 121 (2.9) 0.7184
 Smoking 164 (3.7) 112 (0.8) < 0.0001 52 (3.6) 146 (3.5) 0.7923
 Other infectious pneumonia 1085 (24.4) 184 (1.4) < 0.0001 286 (20.0) 1107 (26.4) < 0.0001
 Tuberculosis 628 (14.1) 14 (0.1) < 0.0001    
 Malnutrition 978 (22.0) 261 (2.0) < 0.0001    
 Corticoids 2550 (57.3) 4504 (33.8) < 0.0001    
 Cystic fibrosis 143 (3.2) 1 (0.0) < 0.0001    
  1. SD standard deviation