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Table 3 Association of clinical manifestations and hematological factors with culture-confirmed sepsis among septic neonates admitted to referral hospitals in Sana’a city, Yemen, in the period from January 15 to March 30, 2020 (N = 199)

From: Neonatal sepsis in Sana’a city, Yemen: a predominance of Burkholderia cepacia

Variable N Culture-confirmed neonatal sepsis
n (%) Chi-square value p value
Clinical manifestations
 Poor feeding
  No 79 58 (73.4) 1.18 0.277
  Yes 120 96 (80.0)   
 Convulsiona
  No 182 137(75.3)   0.015
  Yes 17 17 (100)   
 Irritabilitya
  No 164 124(75.6)   0.266
  Yes 35 30 (85.7)   
 Jaundice
  No 141 107(75.9) 0.62 0.430
  Yes 58 47 (81.0)   
 Lethargy
  No 70 52 (74.3) 0.59 0.411
  Yes 129 102(79.1)   
 Respiratory ratea
  Normal 53 40 (75.5)   0.96
  Tachypnea 135 105 (77.8)   
  Apnea 11 9 (81.8)   
 Temperaturea
  Normal 154 115 (74.7)   0.045
  Hyperthermia 36 33 (91.7)   
  Hypothermia 9 6 (66.7)   
Hematological factors
 C-reactive protein     
  Non-reactive < 6 ml/dl 74 48 (64.9) 11.3 0.001
  Reactive 113 97 (85.8)   
 WBCa
  Normal 65 49 (75.4)   0.891
  High 126 99 (78.6)   
  Low 6 5 (83.3)   
 Plateletsa
  Normal 124 91 (73.4)   0.158
  High 5 5 (100)   
  Low 68 57 (83.8)   
  1. N, number of suspected neonates; n, number of culture-confirmed septic neonates; normal WBC 4000–10,000/mm3; normal platelets 150,000–450,000; normal respiratory rate, 30–50permint
  2. aFisher’s exact test was used