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Table 1 Association between ecological determinants and zika virus infection in Goiás, Central-West region of Brazil, 2016–2018: multivariable analysis

From: Zika virus infection and microcephaly: spatial analysis and socio-environmental determinants in a region of high Aedes aegypti infestation in the Central-West Region of Brazil

Variables Model 1 Model 2 Model 3
aIRR (95% CI) β SE p-value aIRR (95% CI) β SE p-value aIRR (95% CI) β SE p-value
Sociodemographic/economic             
 Gross domestic product per capita 1.06 (0.93–1.20) 0.058 0.070 0.376 0.98 (0.85–1.14)  − 0.018 0.073 0.811 0.92 (0.77–1.10)  − 0.083 0.082 0.350
 Municipal human development index 1.98 (0.60–6.48) 0.684 1.199 0.257 1.19 (0.30–4.77) 0.175 0.844 0.805 0.59 (0.11–2.99)  − 0.522 0.490 0.527
 Gini index 0.85 (0.38–1.92)  − 0.157 0.353 0.703 0.98 (0.48–2.02)  − 0.016 0.362 0.811 1.24 (0.53–2.88) 0.216 0.533 0.615
 Population density 1.08 (0.99–1.17) 0.044 0.004 0.073 1.06 (0.98–1.14) 0.054 0.041 0.966 1.09 (1.07–1.10) 0.082 0.049  < 0.001
Health             
 Dengue fever incidence rate      1.04 (1.01–1.06) 0.036 0.010 0.001 1.03 (1.01–1.06) 0.033 0.045 0.003
 Chikungunya incidence rate      0.89 (0.48–1.62)  − 0.120 0.274 0.696 0.99 (0.56–1.75)  − 0.010 0.288 0.970
 Population coverage of community health agents      0.99 (0.84–1.18)  − 0.004 0.087 0.962 1.05 (0.88–1.26) 0.051 0.098 0.578
 Population coverage of endemic disease control agents      0.80 (0.61–1.05)  − 0.221 0.109 0.102 0.74 (0.57–0.96)  − 0.052 0.098 0.023
Environmental             
 Proportion of the population without access to sewage collection and treatment          0.95 (0.87–1.04) 0.533 0.042 0.241
 Proportion of the population living in a household with piped water          1.70 (0.83–3.52) 0.427 0.630 0.149
 Proportion of the population living in a garbage collection site          1.53 (0.46–5.06) 0.633 0.935 0.483
 Average rainfall          1.88 (1.35–2.61) 0.348 0.313  < 0.001
 Building infestation index for Aedes larvae          1.42 (1.32–1.52) 0.345 0.050  < 0.001
 AIC 9433.6 7752.2 6889.3
 R2 0.063 0.229 0.315
  1. Model 1: sociodemographic/economic variables
  2. Model 2: sociodemographic/economic variables + health variables
  3. Model 3: Sociodemographic/economic variables + health and environmental variables
  4. AIC Akaike information criterion; β regression coefficient; 95% CI 95% confidence interval; aIRR adjusted incidence rate ratio; SE standard error; R2 determination coefficient; *Wald test