Fig. 4

Double time-protein proximity heatmap resulting from the analysis of the 125 main spectrum profiles (MSP) of S. pneumoniae. The interest cluster is indicated. The bottom-right hemi-matrix shows the samples’ proteinic proximity. The top-left hemi-matrix shows the samples’ time concomitance. The colorscale is the same for the two hemi-matrices: blue corresponds to the largest distances and red to the closest ones. Spectra with closed time-protein distances appears as a square in hot colour along the matrix diagonal, as subtree A. The stars near the leaves are the spectra involved in the alarm emitted by BALYSES. Subtree D has a less epidemiological interest with a temporal heterogeneity