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Table 3 Univariate and multivariate analysis of rifampicin concentration considering age, gender and ethnicity

From: Real-life isoniazid and rifampicin plasma concentrations in children: a tool for therapeutic drug monitoring of tuberculosis

 

n (%)

Median plasma concentration μg/ml (IQR)

Univariate analysis

p

Multivariate analysis

p

Age groups (years)

    

 ≤ 2 years

6

10.46 (0.13–13.16)

  

 2–12 years

41

13.17 (8.45–17.30)

0.11

 < 0.001

 > 12 years

21

8.96 (0.13–12.35)

0.61

0.15

Gender

    

 Male

51

10.63 (3.51–16.28)

0.24

0.31

 Female

17

12.16 (10.29–17.03)

  

Ethnicity

    

 African

5

17.30 (13.16–18.90)

0.02

 < 0.01

 Asiatic

7

14.26 (7.44–18.32)

0.03

0.05

 South American

13

12.16 (10.87–16.67)

0.04

0.05

 Caucasian

43

9.6 (0.19–15.72)

  
  1. Value reported in bold those statistically significant (p < 0.05)
  2. IQR interquartile range