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Table 1 Clinical characteristics of the patient population at admission

From: IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria

Characteristic

Malaria

HIV

Malaria + HIV

N

61

58

70

Age, years

40 (18–79)

39 (22–84)

40 (20–65)

Sex, females (% (n))

41 (25)

50 (29)

50 (35)

Haemoglobin (g/dL)

11.2 (3.2–17.0)

8.9 (2.9–15.2)

9.4 (2.5–15.7)

Leukocytes (× 109/L)

6.9 (1.3–15.5)

8.2 (0.3–25.4)

7.8 (0.9–21.8)

Platelets (× 109/L)

124 (11–452)

220 (13–682)

90 (8–330)

Se-Creatinine (µmol/L)

127 (57–357)

161 (41–873)

223 (62–1529)

Se-Glucose (mmol/L)

8.7 (3.6–40.5)

6.1 (3.3–10.6)

6.12 (1.5–27.0)

Liver failure (%)a

5 (3/61)

7 (4/57)

17 (12/70)

Coagulation disturbance (%)b

2 (1/61)

0

13 (9/70)

Cerebral affection (%)c

25 (15/61)

33 (19/58)

31 (22/70)

Systolic blood pressure

122 (70–240)

115 (90–160)

115 (80–170)

Respiratory rate

22 (12–68)

29 (12–56)

24 (16–42)

Case fatality rate (%)

1.7 (1/59)

27.8 (15/54)

13.0d (9/69)

Duration of symptoms in days (median)

4.2 (1–28)

7 (1–365)

8.6 (1–180)

Severe HIVe (%)

n.a

83 (48/58)

59 (41/70)

HIV viral load in copies/mL (median)

n.a

1.3 × 104

1.8 × 104

Median CD4 lymphocyte count (cells/μL)f

n.a

136

206

Effective ARTg prior to admission (%)

n.a

19 (10/53)

14 (9/64)

  1. Values in mean (min–max) or percentage and proportion. The 52 healthy controls are not included aDefined as jaundice/bilirubine > 50 µmol/L, bDefined as bleeding disturbances/hemolysis, cDefined as GCS ≤ 11, convulsions or confusion, dOne patient died of non-malarial cause, he was excluded, eSevere HIV = WHO stage 3 or 4, fCD4 T-cell count were only obtained in 8 (HIV only) and 11 (HIV + malaria) patients, gART = antiretroviral therapy = HIV treatment. ‘‘Effective’’ is defined as ‘‘Previous known ART and undetectable HIV-RNA in the plasma’’, in relation to all HIV-patients with and without malaria