Adverse event | Reaction n (%) | How adverse events were resolved | ||
---|---|---|---|---|
Managed clinically | Regimen changed | Otherb | ||
Nausea/vomiting | 14 (20.3%) | 14 (100%) | ||
Headache | 15 (21.7%) | 15 (100%) | ||
Diarrhea | 2 (2.9%) | 2 (100%) | ||
Burning pains in the lower limbs | 20 (29.0%) | 18 (90%) | 1 (5%) | 1 (5%) |
Arthralgia | 12 (17.4%) | 12 (100%) | ||
Seizures | 1 (1.4%) | 1 (100%) | ||
Rash | 1 (1.4%) | 1 (100%) | ||
Psychiatric manifestationsa | 9 (13.0%) | 9 (100%) | ||
Hypothyroidism | 2 (2.9%) | 2 (100%) | ||
Visual disturbances (Reduced visual acuity) | 10 (14.5%) | 10 (100%) | ||
Hearing disturbance (Bilateral mild through to profound hearing loss) | 21 (30.4%) | 21 (100%) | ||
Dizziness | 13 (18.8%) | 13 (100%) |