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Table 1 Characteristic of included studies

From: High resolution melting assay as a reliable method for diagnosing drug-resistant TB cases: a systematic review and meta-analysis

Author

Year

Country

Subjects

R/S

Gene

TP (n)

FP (n)

FN (n)

TN (n)

NOS

Refs.

Pietzka

2009

Austria

Multidrug-resistant TB

49/19

rpoB

44

2

5

17

8

[18]

Choi

2010

Korea

Isoniazid resistance

Rifampicin resistance

100/117

73/124

katG, inhA

rpoB

90

72

0

0

10

1

117

124

10

[19]

Ong

2010

Singapore

Isoniazid resistance

Rifampicin resistance

53/6

28/31

katG and mab-inhA

rpoB

52

25

1

0

1

3

5

31

8

[20]

Ramirez

2010

United States

Multidrug-resistant TB

148/104

katG, inhA

rpoB

126

2

22

102

8

[21]

Wang

2011

China

Streptomycin resistance

30/0

rpsL

21

0

9

0

5

[22]

Chen

2011

Australia

Isoniazid resistance

Rifampicin resistance

Ofloxacin resistance

69/46

54/61

41/74

katG and mab-inhA

rpoB

gyrA

67

51

41

0

1

1

2

3

0

48

60

73

9

[23]

Lee

2012

Singapore

Fluoroquinolone and Streptomycin resistance

25/28

48/14

gyrA

rpsL

19

42

0

0

6

6

28

14

7

[24]

Yadav

2012

India

Isoniazid resistance

Rifampicin resistance

Streptomycin resistance

35/20

29/20

34/20

katG

rpoB

rpsL

30

27

21

2

0

0

5

2

13

18

20

20

9

[25]

Nagai

2013

Japan

Isoniazid resistance

Rifampicin resistance

Ethambutol resistance

Streptomycin resistance

12/15

10/17

8/19

11/16

katG, mab-inhA

rpoB

embB

rpsL, rrs

11

10

8

11

0

2

0

1

1

0

0

0

15

15

19

15

10

[26]

Nour

2013

Egypt

Isoniazid resistance

Rifampicin resistance

20/10

13/17

katG, rpoB

17

12

0

0

3

1

10

17

6

[27]

Haeili

2014

Iran

Isoniazid resistance

Rifampicin resistance

21/54

20/54

katG

rpoB

18

19

0

0

3

1

54

54

8

[28]

Pholwat

2014

United States

Pyrazinamide resistance

55/41

pncA

34

7

21

34

8

[29]

Malhotra

2015

India

Rifampicin resistance

103/116

rpoB

93

3

10

113

9

[30]

Pholwat

2015

United states

Drug-resistant TB

186/41

161/58

80/123

107/304

40/180

56/57

inhA or katG

rpoB

embB

rpsL, rrs, eis

gyrA-gyrB

pncA

174

153

62

89

31

49

0

11

35

18

3

2

12

8

18

18

9

7

41

47

88

286

177

55

10

[31]

Osman

2016

Africa

Pyrazinamide resistance

29/66

pncA

14

17

15

49

7

[32]

Galarza

2016

Peru

Multidrug-resistant TB

Isoniazid resistance

Rifampicin resistance

78/89

78/89

78/89

katG, inhA

rpoB

77

77

77

2

2

0

1

1

1

87

87

89

8

[33]

Anthwal

2017

India

Isoniazid resistance

Rifampicin resistance

21/78

11/88

katG, inhA

rpoB

18

10

0

0

3

1

88

88

9

[34]

Rezaei

2017

Iran

Ethambutol resistance

Streptomycin resistance

21/55

25/51

embB

rrs, rpsL

19

22

2

0

2

3

53

51

6

[35]

Sirous

2018

Iran

Isoniazid resistance

Rifampicin resistance

Ofloxacin resistance

16/20

18/20

5/20

katG and mab-inhA

rpoB

gyrA

14

15

4

0

0

0

2

3

1

20

20

20

10

[36]

Negi

2018

India

Multidrug-resistant TB

94/49

katG, rpoB

85

0

9

49

8

[37]

Filipenko

2019

Russia

Pyrazinamide resistance

38/20

pncA

31

3

7

17

7

[38]

Arefzadeh

2020

Iran

Rifampicin resistance

5/75

rpoB

5

8

0

67

8

[39]

Anukool

2020

Thailand

Isoniazid resistance

Rifampicin resistance

34/69

37/70

katG, inhA

rpoB

33

31

4

1

1

6

65

69

9

[40]

Wang

2020

China

Ethambutol resistance

59/163

embB

49

9

10

154

7

[41]