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Table 3 The comparison of the features between RR/MDR-TBM and NRR/MDR-TBM groups

From: Decreased mortality seen in rifampicin/multidrug-resistant tuberculous meningitis treated with linezolid in Shenzhen, China

 

TBM

RR/MDR-TBM

NRR/MDR-TBM

P value

Total

137

12

125

 

Male

98

11

87

0.178

Age(year)

29

29 ± 18

29 ± 12.25

0.927

TB history

18

6

12

 < 0.01

Miliary PTB

71

6

65

0.895

Active PTB

55

6

49

0.466

Extrapulmonary TB

44

4

40

0.819

HIV co-infection

17

2

15

0.992

Type-II diabetes

7

1

6

0.595

Course of disease (days from onset to admission)

10 ± 10

3 ± 12

10 ± 10

0.314

Headache

85

5

80

0.128

Fever

93

8

85

0.433

Vomiting

40

2

38

0.505

Convulsion

12

3

9

0.123

Consciousness disorder

56

7

49

0.198

Neck stiff

114

10

105

0.725

Cranial nerve impairment

23

2

21

0.695

Pathological sign

33

6

33

0.084

Paralysis

9

1

8

0.725

GCS score

13.13 ± 2.57

12.25 ± 2.83

13.22 ± 2.54

0.215

BMRC gradeI

76

4

72

0.190

BMRC gradeII

33

4

29

0.667

BMRC grade III

28

4

24

0.432

Death/total

24/87

3/12

21/75

0.895

Hyponatremia

35

5

30

0.180

IGRA (positive/total)

98/128

8/11

90/117

0.954

CD4 T cell count

221 ± 189

213 ± 188

280 ± 196

0.156

CSF examination

 Elevated CSF pressure

72

7

65

0.675

 WBC(106/L)

231 ± 87.5

104 ± 442.3

287 ± 389

0.060

 NEUT%

56.8 + 24.8

57.5 ± 24.9

56.8 ± 24.9

0.961

 PRO (mg/L)

1843 ± 1201

1885 ± 1222

1407 ± 71.4

0.167

 CL (mmol/L)

110 ± 12.3

110.6 ± 12.5

112.7 ± 10.96

0.385

 GLU (mmol/L)

1.9 ± 1.2

1.9 ± 1.2

2.0 ± 1.0

0.522

 ADA (U/L)

8.7 ± 15.6

5.4 ± 4.2

9.0 ± 16.3

0.172

  1. (N)RR/MDR TBM, (non) rifampicin/multidrug-resistant tuberculous meningitis
  2. PTB, pulmonary tuberculosis; HIV, human immunodeficiency virus; GCS, Glasgow Coma Scale; BMRC, the modified British Medical Research Council; Grade I (GCS 15; no focal neurological signs), grade II (GCS 11–14, or 15 with focal neurological signs), and grade III (GCS ≤ 10) disease. IGRA, interferon gamma release assay; CSF, cerebrospinal fluid; WBC, white blood cell; NEUT, neutrophilic granulocyte; PRO, total protein; CL, chloride; GLU, glucose; ADA, adenosine deaminase