Table 1 Demographic and laboratory data in the study cohorts
Variable | Developing cohort (n = 129) | Validation cohort (n = 239) | Prospective cohort (n = 497) | P value (developing vs validation cohort) | P value (developing vs prospective cohort) | P value (validation vs prospective cohort) |
|---|---|---|---|---|---|---|
Age (years), median (IQR) | 71 (57–79) | 67 (53–95) | 70 (56–81) | p < 0.03 | 0.99 | p < 0.004 |
Male sex, n (%) | 56 (43.0) | 134 (56.1) | 292 (58.8) | 0.12 | p < 0.02 | 0.99 |
Hemoglobin level (g/dL), median (IQR) | 12.9 (10.7–14.2) | 13.6 (12.4–14.8) | 13.2 (11.8–14.5) | p < 0.001 | p < 0.048 | p < 0.046 |
Mean corpuscular volume (fL), median (IQR) | 87.2 (83.6–91.1) | 88.6 (86.2–91.5) | 90.2 (86.9–94.0) | p < 0.027 | p < 0.001 | p < 0.001 |
Leukocyte count, (103/µL), median (IQR) | 6.8 (4.9–9.5) | 6.2 (4.8–8.8) | 8.1 (5.9–11.3) | 0.56 |  < 0.001 | p < 0.001 |
Platelet count (103/µL), median (IQR) | 192 (151–258) | 207 (168–259) | 215 (167–287) | 0.50 | 0.07 | 0.99 |
C-reactive protein (mg/dL), median (IQR) | 63.2 (18.5–132.7) | 44.8 (10.0–102.1) | 48.4 (10.2–123.5) | 0.12 | 0.11 | 0.99 |
Creatinine, mg/dL | 1.01 (0.76–1.54) | 0.90 (0.75–1.12) | 1.16 (0.93–1.53) |  < 0.001 | 0.007 | 0.001 |
Sodium (mEq/L), median (IQR) | 135.7 (132.4–138.7) | 140.9 (138.9–142.9) | 137 (134–140) | p < 0.001 | p < 0.04 | p < 0.001 |
Potassium (mEq/L), median (IQR) | 4.1 (3.8–4.5) | 4.2 (3.9–4.6) | 4.0 (3.7–4.4) | 0.85 | p < 0.014 | p < 0.001 |