All patients n = 128 | EBV n = 17 | Non-EBV n = 111 | P value | |
---|---|---|---|---|
Demographic characteristics, baseline characteristics | ||||
Age, years | 62 (52–68) | 62 (51.5–72.5) | 61 (52–66) | 0.768 |
Sex | ||||
Men | 66 (51.6) | 10 (58.8) | 56 (50.4) | 0.520 |
Women | 62 (48.4) | 7 (41.2) | 55 (49.6) | 0.520 |
Symptoms | ||||
Respiratory rate | 25 (20–41) | 25 (20–47.5) | 25 (22.25–41.25) | 0.849 |
> 24 breaths per min | 53 (41.4) | 15 (88.2) | 38 (34.2) | < 0.001* |
Systolic pressure, mmHg | 133 (120–147) | 127(116–152.25) | 138 (122–148) | 0.820 |
SpO2,% | 93 (82–97) | 95 (73.5–98.75) | 92 (82–95) | 0.752 |
Heart rate | 94 (86–99) | 86 (84.5–106.5) | 95 (93–100) | 0.611 |
Laboratory test | ||||
White blood cell count, × 109/L | 8.4 (4.6–10.8) | 10.35 (7.925–13.25) | 7.1 (4–9.1) | 0.081 |
Neutrophil % | 89.2 (82.2–92) | 91.2 (88.2–92.3) | 88.9 (72.7–91.6) | 0.288 |
Lymphocyte count, × 109/L | 0.58 (0.4–0.67) | 0.54 (0.335–0.6525) | 0.59 (0.4–0.75) | 0.0002** |
Lymphocyte% | 6.14 (4.73–12.79) | 5.013 (3.92–6.77) | 6.42 (5.61–15.59) | 0.278 |
Platelet < 100 × 109/L, % | 8 (6.25) | 2 (11.7) | 6 (5.41) | 0.313 |
D-dimer, mg/L | 6.07 (2.26–6.9) | 6.67 (1.85-32.9) | 4.26 (2.26–6.39) | < 0.0001** |
Fibrinogen, g/L | 5.81 (4.92–6.32) | 6.15 (5.6-6.52) | 4.93 (4.625–6.23) | 0.177 |
Albumin, g/L | 27.3 (25.2–29.7) | 25.6 (22.65–28.42) | 28.2 (26.9–30.2) | 0.03* |
Potassium, mmol/L | 3.6 (3.22–3.9) | 3.6 (3.2–4.0) | 3.515 (3.255–3.877) | 0.910 |
Calcium, mmol/L | 1.81 (1.14–1.92) | 1.91 (1.855–2) | 1.18 (1.13–1.9) | < 0.001* |
Sodium, mmol/L | 142 (141–145) | 141 (140–141) | 142 (141–145) | 0.743 |
Procalcitonin, µg/L | 0.34 (0.135–0.88) | 0.475 (0.31–1.72) | 0.12 (0.07-0.12) | 0.257 |
C-reactive protein, mg/ | 121.8 (42.31–259.6) | 262.4 (122.3–271) | 53.9 (17.79–137) | 0.004* |
pH | 7.42 (7.39–7.49) | 7.46 (7.39–7.46) | 7.41 (7.385–7.47) | 0.347 |
PaO2, mmHg | 54(48.5-150.5) | 49.0 (43–106) | 57 (49.5–170) | 0.432 |
PaCO2, mmHg | 38.2 (34.4–42.15) | 34.2(28.6–47.82) | 38.8 (37.75–42.15) | 0.483 |
Lac, mmol/L | 1.05 (0.625–1.65) | 1 (0.6–1) | 1.1 (0.6–1.85) | 0.821 |
HCO3– | 24.75 (23.65–29.15) | 26.2 (22.8–26.2) | 24.1 (23.7–29) | 0.726 |
Clinical outcomes | ||||
Acute myocardial injury% | 11 (8.59) | 2 (11.76) | 9 (8.11) | 0.640 |
Acute liver injury% | 11 (8.59) | 2 (11.76) | 9 (8.11) | 0.640 |
Acute kidney injury% | 12 (9.37) | 2 (11.76) | 10 (9.01) | 0.661 |
Sepsis% | 10 (7.81) | 2 (11.76) | 8 (7.21) | 0.621 |
Respiratory failure% | 50 (39.1) | 13 (76.5) | 37 (33.3) | 0.001* |
ARDS% | 53 (41.4) | 15 (88.2) | 38 (34.2) | < 0.001* |
Heart failure% | 4 (3.12) | 1(5.88) | 3 (2.71) | 0.439 |
Septic shock% | 4 (3.12) | 0 | 4 (3.60) | 1 |
Coagulopathy% | 1 (0.781) | 1 (5.88) | 0 | 0.133 |
Secondary infection% | 2 (1.56) | 1 (5.88) | 1 (0.90) | 0.249 |
Hypoproteinaemia% | 59 (46.1) | 15 (88.2) | 44 (39.6) | < 0.001* |
Acidosis% | 3 (2.34) | 1 (5.88) | 2 (1.80) | 0.350 |
28-day mortality% | 14 (10.9) | 5 (29.4) | 9 (8.11) | 0.0046* |
14-day mortality% | 10 (7.81) | 5 (29.4) | 5 (4.5) | 0.0046* |