Table 2 Clinical presentation, CSF findings, SFTS-DNA testing and imaging findings in patients with SFTS-associated encephalopathy/encephalitis who underwent CSF testing (n = 7)
Case no. | Age /sex | Days to neurological presentation | Neurological presentation | CSF findings | Blood SFTSV- RNA load (copies/ml) | Brain CT | Brain MRI | Co-infection | Outcome | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
WBC (*106/L) | Neutrophils (%) | Lymphocyte (%) | Protein (mg/L) | Glucose (mmol/L) | Chlorine (mmol/L) | IgG (mg/L) | SFTSV-RNA load (copies/ml) | |||||||||
Normal range | 0–8 | 0–6 | 40–80 | 140–450 | 2.5–4.5 | 120–132 | 4.8–58.6 | Negative | Negative | |||||||
1 | 61/M | 6th day | Unconsciousness, seizure | 9.0 | 35 | 65 | 736 | 5.14 | 130.9 | 187 | 103/L | 106/L | Lacunar infarction | Chronic hypoxia changes in white matter | IPA | Died |
2 | 71/M | 4th day | Unconsciousness | 6.0 | 66.6 | 33.4 | 976 | 2.41 | 123 | 148 | 103/L | 104/L | Lacunar infarction | Chronic hypoxia changes in white matter | IPA, bacteremia | Died |
3 | 71/F | 4th day | Altered mental status, disorientation | 5.0 | 20 | 80 | 469 | 3.22 | 130 | NA | 103/L | 106/L | Lacunar infarction | NA | IPA | Died |
4 | 64/M | 4th day | Unconsciousness, seizure | 1.0 | 0 | 100 | 572 | 3.97 | 126.2 | 53.1 | 103/L | 106/L | Lacunar infarction | NA | Bacteremia | Died |
5 | 45/M | 7th day | Headache, altered mental status | 1.0 | 0 | 100 | 542 | 3.26 | 133 | 29.5 | Negative | 106/L | Lacunar infarction | Chronic hypoxia changes in white matter | No | Survived |
6 | 76/F | 3rd day | Unconsciousness | 0 | 0 | 0 | 914 | 5.35 | 135.3 | 61 | Negative | 108/L | NA | NA | No | Died |
7 | 28/M | 5th day | Headache, altered mental status | 50 | 36 | 54 | 1226 | 1.33 | 129 | NA | Negative | 108/L | ICH | Multiple abnormal signal shadows | IPA | Died |
8 | 61/F | 4th day | Headache, altered mental status | 3 | 33.3 | 66.7 | 498 | 9.77 | 119 | NA | NA | 106/L | Normal | NA | IPA, bacteremia | Died |
9 | 49/M | 6th day | Headache, altered mental status | 4 | 25 | 75 | 416 | 4.02 | 126 | NA | NA | 106/L | NA | NA | IPA, bacteremia | Died |
10 | 75/M | 4th day | Headache, altered mental status | 7 | 50 | 50 | 904 | 6.16 | 138 | NA | NA | 104/L | Lacunar infarction | NA | IPA, bacteremia | Died |