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Table 4 Association between the most common co-occurring multimorbidity index conditions and the risk of severe SARS-CoV-2 infection: UK Biobank (N = 360,283)

From: Patterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the U.K.

Risk of severe SARS-CoV-2 infection

(hospitalisation or death)

Adjusted OR (95% CI)

CKD & diabetes (n = 713)

4.93 (3.36, 7.22)

Heart failure & hypertension (n = 81)

4.47 (1.40, 14.29)

COPD & hypertension (n = 343)

2.70 (1.38, 5.28)

CKD & hypertension (n = 3817)

2.58 (2.00, 3.34)

Atrial fibrillation & hypertension (n = 1052)

2.44 (1.50, 3.96)

Stroke & hypertension (n = 2236)

2.16 (1.55, 3.02)

Myocardial infarction & hypertension (n = 3763)

1.98 (1.51, 2.59)

Diabetes & hypertension (n = 9025)

1.92 (1.59, 2.33)

Myocardial infarction & angina (n = 2814)

1.78 (1.30, 2.43)

Angina & hypertension (n = 5802)

1.66 (1.31, 2.11)

Cancer & hypertension (n = 7783)

1.58 (1.24, 2.01)

Asthma & hypertension (n = 11,242)

1.29 (1.03, 1.60)

  1. Reference is those without the stated two co-occurring conditions (i.e. with asthma and hypertension vs. without asthma and hypertension [reference])
  2. Most common co-occurring multimorbidity conditions illustrated in Fig. 1
  3. Models adjusted for age at test, sex, ethnicity, deprivation, smoking status, body mass index, air pollution, 25‐hydroxyvitamin D, cardiorespiratory fitness, C-reactive protein, season at blood draw, and regular intake of vitamin D supplement
  4. OR odds ratio, CI confidence interval, CKD chronic kidney disease, CPD chronic obstructive pulmonary disease
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BMC Infectious Diseases

ISSN: 1471-2334

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