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Table 1 Demographic characteristics, clinical features, investigations, complications and outcome of study participants

From: A review of clinical profile, complications and antibiotic susceptibility pattern of extensively drug-resistant (XDR) Salmonella Typhi isolates in children in Karachi

Demographic features

Number (%)

Male

391 (58)

Female

289 (43)

Age in years median (IQR)

5 (2–8)

Place of presentation

 

 E/R

612 (90)

 OPD

65 (9.6)

 Inpatient

3 (0.4)

Clinical features on presentation (680)

Number (%)

Fever

680 (100)

Vomitting

242 (36)

Diarrhea

174 (26)

Anorexia

140 (21)

Cough

126 (19)

Abdominal pain

125 (18)

Hepatomegaly

63 (9)

Splenomegaly

22 (3)

Urinary symptoms

14 (2)

Rash

12 (2)

Bleeding per rectum

4 (1)

Lab investigations

Number (%)

Raised CRP > 5 (415)

395 (95)

Hyponatremia (severe + moderate combined) (178)

74 (41)

Acidosis (178)

65 (37)

Hypokalemia (severe + moderate combined) (178)

59 (33)

Severe thrombocytopenia (< 50,000 × 109/L) (676)

24 (4)

Raised serum creatinine (151)

4 (3)

Severe anemia (Hb < 5 gm/dl) (676)

9 (1)

Complications

Number (%)

Mesentric lymphadenopathy (on abdominal ultrasound), (62)

11 (18)

Encephalopathy (101)

16 (16)

Hepatitis, LFT (81)

11 (14)

Peritoneal free fluid (on abdominal ultrasound) (62)

8 (13)

Bi-cytopenia (676)

67 (10)

Pleural effusion (on abdominal ultrasound) (62)

6 (10)

Cholecystitis (on abdominal ultrasound) (62)

4 (6)

Shock (seen in 101 admitted patients)

5 (5)

Encephalitis (seen in 101 admitted patients)

4 (4)

Aphasia (seen in 101 admitted patients)

4 (4)

Pancytopenia, done in 676

16 (2)

Outcomes

 

Patients with known outcomes (270)

 

 Cured

234 (87)

 Delayed response

32 (12)

 Died

4 (1)

Patients with unknown outcomes (410)

 

 Lost to follow up

351 (86)

 LAMA/referred out

59 (14)

  1. LAMA leave against medical advice