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Table 1 Cases of ascending aortic mycotic pseudoaneurysm formed due to Pseudomonas aeruginosa infection after HTX

From: Pseudoaneurysm of the ascending aorta: case report of a donor-derived Pseudomonas infection in a heart transplant recipient

Age (years) Sex Time after HTX (months) Recent verified infection or events predisposing to infection Antimicrobial therapy Surgical treatment Follow-up (months) Clinical
outcome
Reference
39 Male 5 Pseudomonas aeruginosa septicaemia and positive urine culture iv. Tobramycin, ceftazidime (6 weeks) Resection, end-to-end anastomosis 8 unrelated death Palac RT,
et al. 1991
26 Male 15 Cystic fibrosis, heart–lung transplantation, Pseudomonas aeruginosa bronchitis iv. Unspecified antibiotics (61 days)
po. ciprofloxacin (continuously)
Direct repair (autologous pericardium) 5 operation due to recurrence, (resection of pseudoaneurysm and heterologous graft implantation), then unrelated death after 7 months Cassart M,
et al. 1994
31 Male 2 N/A N/A Resection, allograft implantation N/A reoperation due to recurrence, then recovered McGiffin DC,
et al. 1994
60 Male N/A Diabetes mellitus, mediastinitis iv. Unspecified antibiotics (6 weeks) Repair with allograft patch 34 recovered Knosalla C,
et al. 1996
N/A N/A 8 Pseudomonas pneumonia Unspecified antibiotics (4–6 weeks) Collagen-sealed vascular graft implantation 2 reoperation due to recurrence, then death due to bleeding through bronchial fistula Koyanagi T,
et al. 1999
57 Male 29 Infected retained LVAD driveline
(Pseudomonas aeruginosa)
iv. Unspecified antibiotics (≥ 6 weeks) Resection, prosthetic graft implantation, pectoralis flap 1 recovered Tang GHL,
et al. 2011
44 Male 1.4 RVAD outflow graft infection, septicaemia (Pseudomonas aeruginosa) Unspecified antibiotics After 3 weeks: resection, allograft implantation N/A N/A Mirzaee S,
et al. 2016
45 Male 1.1 Pseudomonas isolated from previous LVAD exit site iv. Ceftolozane/tazobactam (8 weeks)
po. ciprofloxacin (lifelong)
Resection, allograft implantation 8,3 recovered Aye C,
et al. 2017
  1. Eight cases of ascending aortic mycotic pseudoaneurysm formed due to P. aeruginosa infection after HTX were found in the literature. All of them were male patients with a median age of 44 years. The median time between HTX and diagnosis was 5 month. Ventricular assist device related infection was common in medical history. Combined surgical and antibiotic treatment was performed, which however resulted in a recurrence rate of 43%. N/A: not available