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Table. 1 HScore for reactive hemophagocytic syndrome

From: Hemophagocytic syndrome secondary to SARS-Cov-2 infection: a case report

Variable Points Patient’s score
Known underlying immunosuppression
HIV positive or receiving long‐term immunosuppressive therapy (i.e., glucocorticoids, cyclosporine, azathioprine)
No 0 No
Yes  + 18  
Temperature, °F (°C)  < 101.1 (< 38.4) 0  
101.1–102.9 (38.4–39.4)  + 33  
 > 102.9 (> 39.4)  + 49 39.5 °C
Organomegaly No 0  
Hepatomegaly or splenomegaly  + 23 Splenomegaly
Hepatomegaly and splenomegaly  + 38  
Number of cytopenias
Defined as hemoglobin ≤ 9.2 g/dL (≤ 5.71 mmol/L) and/or WBC ≤ 5000/mm3 and/or platelets ≤ 110,000/mm3
1 lineage 0  
2 lineages  + 24  
3 lineages  + 34 Hb 7.7 g/dL, WBC 3700/mm3, platelets 27,000/mm3
Ferritin, ng/mL (or μg/L)  < 2,000 0  
2000–6000  + 35  
 > 6000  + 50 20,696 ng/mL
Triglyceride, mg/dL (mmol/L)  < 132.7 (< 1.5) 0  
132.7–354 (1.5–4)  + 44  
 > 354 (> 4)  + 64 428 mg/dL
Fibrinogen, mg/dL (g/L)  > 250 (> 2.5) 0  
 ≤ 250 (≤ 2.5)  + 30 74 mg/dL
AST (aspartate aminotransferase), U/L  < 30 0  
 ≥ 30  + 19 59 U/L
Hemophagocytosis features on bone marrow aspirate No 0 No
Yes  + 35  
Total    269 points (> 99% probability of hemophagocytic syndrome)