Table. 1 Characteristics of TDF/TDF (N = 31) and TDF/TAF groups (N = 98)
TDF/TDF groupN = 31 | TDF/TAF groupN = 98 | Comparisonp-value | |
|---|---|---|---|
Age (years) | 50 ± 11 | 50 ± 12 | 0.79 |
Sex = Male | 22 (71.0) | 63 (64.3) | 0.49 |
Smoking | 0.26 | ||
Non-smoker | 16 (51.6) | 51 (53.7) | |
Ex-smoker | 3 (9.7) | 19 (20.0) | |
Smoker | 12 (38.7) | 25 (26.3) | |
Total | 31 (100.0) | 95 (100.0) | |
Ethnicity | 0.41 | ||
Caucasian | 15 (48.4) | 54 (55.1) | |
African | 16 (51.6) | 41 (41.8) | |
Other | 0 (0.0) | 3 (3.1) | |
Treated hypertension | 5 (16.1) | 25 (25.5) | 0.28 |
Treated dyslipidemia | 4 (12.9) | 11 (11.2) | 0.80 |
Familial cardiovascular event | 1 (3.2) | 4 (4.1) | 0.83 |
Diabetes | 1 (3.2) | 9 (9.2) | 0.28 |
In 2016 | Before switch | ||
Triglycerides (mg/dL) | 134 ± 82 | 123 ± 65 | 0.43 |
Total cholesterol (mg/dL) | 184 ± 39 | 183 ± 38 | 0.90 |
LDL cholesterol (mg/dL) | 107 ± 34 | 103 ± 32 (N = 97) | 0.71 |
HDL cholesterol (mg/dL) | 51 ± 12 | 56 ± 17 (N = 97) | 0.18 |
Non-HDL cholesterol (mg/dL) | 133 ± 39 | 128 ± 37 (N = 97) | 0.45 |
Total cholesterol /HDL ratio | 3.8 ± 1.2 | 3.6 ± 1.2 (N = 97) | 0.30 |
Weight (kg) | 74.7 ± 14.8 | 77.8 ± 15.9 | 0.34 |
BMI (kg/m2) | 25.1 ± 4.8 | 26.3 ± 4.9 (N = 88) | 0.24 |
DAD-R (%) | 2.1 (0.9; 3.2) (N = 30) | 1.5 (0.6; 4.0) (N = 76) | 0.50 |
CD4 (103/mm3) | 712 (509; 903) | 683 (497; 928) (N = 97) | 0.97 |
Time on TDF (years) | 6 (5; 8) | 6 (2; 8) | 0.11 |