Biomarker | Cut-off | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) |
---|---|---|---|---|---|
IL-6 | 125 pg/ml | 75 (21.9–98.7) | 100 (93.9–99.9) | PR 5%: 100 (56.6–100) PR 10%: 100 (56.6–100) PR 15%: 100 (56.6–100) | PR 5%: 98.7 (93.3–99.8) PR 10%: 97.3 (86.8–99.5) PR 15%: 95.8 (80.6–99.2) |
Neutrophils | 13.8 × 109/L | 100 (39.8–100) | 77.3 (66.2–86.2) | PR 5%: 18.8 (13.3–26.1) PR 10%: 32.9 (24.4–42.7) PR 15%: 43.8 (33.9–54.2) | PR 5%: 100 (87.8–100) PR 10%: 100 (87.8–100) PR 15%: 100 (87.8–100) |
CRP | 7 mg/dl | 100 (39.8–100) | 82.7 (72.2–90.4) | PR 5%: 23.3 (15.6–33.2) PR 10%: 39.1 (28.1–51.2) PR 15%: 50.4 (38.3–62.5) | PR 5%: 100 (92–7-100) PR 10%: 100 (92–7-100) PR 15%: 100 (92–7-100) |
Procalcitonin | 1.3 ng/ml | 75 (19.4–99.4) | 82.7 (72.2–90.4) | PR 5%: 18.5 (9–7-32.6) PR 10%: 32.5 (18.5–50.5) PR 15%: 43.3 (26.5–61.8) | PR 5%: 98.4 (92–99.7) PR 10%: 96.7 (84.5–99.4) PR 15%: 94.9 (77.4–99) |