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Table 4 Diagnostic tests of IL-6 and other significant biomarkers for the prediction of SBI

From: Interleukin 6 as a marker of severe bacterial infection in children with sickle cell disease and fever: a case–control study

Biomarker Cut-off Sensitivity %
(95% CI)
Specificity %
(95% CI)
PPV %
(95% CI)
NPV %
(95% CI)
IL-6 125 pg/ml 75 (21.9–98.7) 100 (93.9–99.9) PR 5%: 100 (56.6–100)
PR 10%: 100 (56.6–100)
PR 15%: 100 (56.6–100)
PR 5%: 98.7 (93.3–99.8)
PR 10%: 97.3 (86.8–99.5)
PR 15%: 95.8 (80.6–99.2)
Neutrophils 13.8 × 109/L 100 (39.8–100) 77.3 (66.2–86.2) PR 5%: 18.8 (13.3–26.1)
PR 10%: 32.9 (24.4–42.7)
PR 15%: 43.8 (33.9–54.2)
PR 5%: 100 (87.8–100)
PR 10%: 100 (87.8–100)
PR 15%: 100 (87.8–100)
CRP 7 mg/dl 100 (39.8–100) 82.7 (72.2–90.4) PR 5%: 23.3 (15.6–33.2)
PR 10%: 39.1 (28.1–51.2)
PR 15%: 50.4 (38.3–62.5)
PR 5%: 100 (92–7-100)
PR 10%: 100 (92–7-100)
PR 15%: 100 (92–7-100)
Procalcitonin 1.3 ng/ml 75 (19.4–99.4) 82.7 (72.2–90.4) PR 5%: 18.5 (9–7-32.6)
PR 10%: 32.5 (18.5–50.5)
PR 15%: 43.3 (26.5–61.8)
PR 5%: 98.4 (92–99.7)
PR 10%: 96.7 (84.5–99.4)
PR 15%: 94.9 (77.4–99)