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Table 4 Clinical characteristics of pneumonia with immunocompromised patients in different underlying disease

From: Characteristics of viral pneumonia in non-HIV immunocompromised and immunocompetent patients: a retrospective cohort study

Variables Connective tissue disease, N = 134 Solid organ transplant, N = 60 Nephrotic syndrome or chronic glomerulonephritis,
N = 46
Hematopoiesis diseasesa
N = 22
Idiopathic interstitial pneumonia,
N = 51
Radiotherapy and chemotherapy of malignant solid tumor,
N = 17
P value
Sex, female, n (%) 64 (47.8) 11 (18.3) 11 (23.9) 7 (31.8) 16 (31.4) 3 (17.6) < 0.001
Age, median (IGR) 62.0 (45.0, 70.3) 58.0 (47.0, 63.0) 58.0 (47.8, 65.3) 55.0 (32.8, 69.5) 59.0 (53.0, 69.0) 64.0 (57.0, 67.0) 0.043
Laboratory examination
 White blood cell, × 109/L (IQR) 8.59 (6.30, 11.72) 6.79 (4.47, 9.81) 8.83 (6.44, 11.97) 5.58 (3.21, 9.85) 7.85 (5.73, 11.48) 8.01 (4.21, 10.77) 0.005
 Neutrophils, × 109/L (IQR) 6.99 (5.05, 9.80) 4.63 (3.11, 7.70) 8.20 (5.2, 10.9) 4.19 (1.89, 7.51) 6.45 (4.60, 9.58) 6.73 (2.91, 8.30) 0.001
 Lymphocyte, × 109/L (IQR) 0.81 (0.44, 1.45) 0.95 (0.36, 1.62) 0.62 (0.33, 0.96) 0.70 (0.22, 1.34) 1.09 (0.70, 1.83) 0.80 (0.46, 1.21) 0.039
 Oxygenation index 212.4 (116.8, 291.8) 244.1 (142.4, 338.1) 122.0 (78.6, 206.2) 225.8 (116.1, 368.2) 209.2 (111.3, 328.5) 327.4 (296.2, 413.6) 0.026
Severe pneumonia index score 76.0 (50.8, 103.0) 83.0 (64.3, 100.0) 89.5 (66.8, 119.0) 87.5 (59.3, 119.0) 79.0 (63.0, 91.0) 107.0 (80.0, 125.0) 0.018
CURB65 score > 1 37 (27.6) 17 (28.3) 19 (41.3) 4 (18.2) 15 (29.4) 6 (35.3) 0.421
Imaging features, n (%) 126 (94.0) 59 (98.3) 37 (80.4) 18 (81.8) 51 (100.0) 15 (88.2)
 Consolidation or mass 86 (64.2) 26 (43.3) 27 (58.7) 5 (22.7) 38 (74.5) 8 (47.1) < 0.001
 Ground-glass opacity 65 (48.5) 22 (36.7) 21 (45.7) 11 (50.0) 18 (35.3) 10 (58.8) 0.049
CMV 89 (66.4) 18 (30.0) 41 (89.1) 11 (50.0) 25 (49.0) 7 (41.2) < 0.001
IFV-A 24 (17.9) 18 (30.0) 5 (10.9) 3 (13.6) 12 (23.5) 6 (35.3) 0.086
IFV-B 9 (6.7) 5 (8.3) 0 (0) 0 (0) 5 (9.8) 2 (11.8) 0.229
RSV 26 (19.4) 21 (35.0) 3 (6.5) 2 (9.1) 14 (27.5) 0 (0) 0.001
AdV 3 (2.2) 3 (5.0) 0 (0) 5 (22.7) 0 (0) 1 (5.9) < 0.001
HRV 2 (1.5) 1 (1.7) 0 (0) 4 (18.2) 0 (0) 0 (0) < 0.001
PIV 9 (6.7) 6 (10.0) 0 (0) 3 (13.6) 3 (5.9) 4 (23.5) 0.035
Viral-PCP co-infection 30 (22.4) 3 (5.0) 24 (52.2) 3 (13.6) 9 (17.6) 4 (23.5) < 0.001
Viral-aspergillus co-infection 13 (9.7) 17 (28.3) 5 (10.9) 1 (4.5) 6 (11.8) 2 (11.8) 0.010
Viral-bacteria co-infection 16 (11.9) 12 (20.0) 6 (13.0) 1 (4.5) 2 (3.9) 3 (17.6) 0.134
Viral-atypical co-infection 4 (3.0) 2 (3.3) 3 (6.5) 1 (4.5) 0 (0) 0 (0) 0.518
Nosocomial bacterial infection 26 (19.4) 25 (41.7) 12 (26.1) 5 (22.7) 11 (21.6) 2 (11.8) 0.021
Complications, n (%)
 NIV 41 (30.6) 8 (13.3) 17 (37.0) 4 (18.2) 15 (29.4) 2 (11.8) 0.035
 IMV 41 (30.6) 9 (15.0) 12 (26.1) 3 (13.6) 17 (33.3) 1 (5.9) 0.033
 Respiratory failure 78 (58.2) 21 (35.0) 24 (52.2) 6 (27.3) 28 (54.9) 6 (35.3) 0.004
 ICU care 66 (49.3) 10 (16.7) 28 (60.9) 8 (36.4) 25 (49.0) 2 (11.8) < 0.001
 Septic shock 31 (23.1) 12 (20.0) 17 (37.0) 3 (13.6) 11 (21.6) 5 (29.4) 0.256
 ECMO 8 (6.0) 4 (6.7) 3 (6.5) 1 (4.5) 7 (13.7) 0 (0) 0.297
 In-hospital mortality 40 (30.0) 6 (10.0) 18 (39.1) 3 (13.6) 13 (25.5) 4 (23.5) 0.011
  1. NIV Noninvasive ventilation, IMV Invasive mechanical ventilation, ECMO Extracorporeal membrane oxygenation
  2. aHematopoiesis diseases: Leukemia, lymphoma, bone marrow or hematopoietic stem cell transplantation