Variables | Connective tissue disease, N = 134 | Solid organ transplant, N = 60 | Nephrotic syndrome or chronic glomerulonephritis, N = 46 | Hematopoiesis diseasesa N = 22 | Idiopathic interstitial pneumonia, N = 51 | Radiotherapy and chemotherapy of malignant solid tumor, N = 17 | P value |
---|---|---|---|---|---|---|---|
Sex, female, n (%) | 64 (47.8) | 11 (18.3) | 11 (23.9) | 7 (31.8) | 16 (31.4) | 3 (17.6) | < 0.001 |
Age, median (IGR) | 62.0 (45.0, 70.3) | 58.0 (47.0, 63.0) | 58.0 (47.8, 65.3) | 55.0 (32.8, 69.5) | 59.0 (53.0, 69.0) | 64.0 (57.0, 67.0) | 0.043 |
Laboratory examination | |||||||
 White blood cell, × 109/L (IQR) | 8.59 (6.30, 11.72) | 6.79 (4.47, 9.81) | 8.83 (6.44, 11.97) | 5.58 (3.21, 9.85) | 7.85 (5.73, 11.48) | 8.01 (4.21, 10.77) | 0.005 |
 Neutrophils, × 109/L (IQR) | 6.99 (5.05, 9.80) | 4.63 (3.11, 7.70) | 8.20 (5.2, 10.9) | 4.19 (1.89, 7.51) | 6.45 (4.60, 9.58) | 6.73 (2.91, 8.30) | 0.001 |
 Lymphocyte, × 109/L (IQR) | 0.81 (0.44, 1.45) | 0.95 (0.36, 1.62) | 0.62 (0.33, 0.96) | 0.70 (0.22, 1.34) | 1.09 (0.70, 1.83) | 0.80 (0.46, 1.21) | 0.039 |
 Oxygenation index | 212.4 (116.8, 291.8) | 244.1 (142.4, 338.1) | 122.0 (78.6, 206.2) | 225.8 (116.1, 368.2) | 209.2 (111.3, 328.5) | 327.4 (296.2, 413.6) | 0.026 |
Severe pneumonia index score | 76.0 (50.8, 103.0) | 83.0 (64.3, 100.0) | 89.5 (66.8, 119.0) | 87.5 (59.3, 119.0) | 79.0 (63.0, 91.0) | 107.0 (80.0, 125.0) | 0.018 |
CURB65 score > 1 | 37 (27.6) | 17 (28.3) | 19 (41.3) | 4 (18.2) | 15 (29.4) | 6 (35.3) | 0.421 |
Imaging features, n (%) | 126 (94.0) | 59 (98.3) | 37 (80.4) | 18 (81.8) | 51 (100.0) | 15 (88.2) | – |
 Consolidation or mass | 86 (64.2) | 26 (43.3) | 27 (58.7) | 5 (22.7) | 38 (74.5) | 8 (47.1) | < 0.001 |
 Ground-glass opacity | 65 (48.5) | 22 (36.7) | 21 (45.7) | 11 (50.0) | 18 (35.3) | 10 (58.8) | 0.049 |
CMV | 89 (66.4) | 18 (30.0) | 41 (89.1) | 11 (50.0) | 25 (49.0) | 7 (41.2) | < 0.001 |
IFV-A | 24 (17.9) | 18 (30.0) | 5 (10.9) | 3 (13.6) | 12 (23.5) | 6 (35.3) | 0.086 |
IFV-B | 9 (6.7) | 5 (8.3) | 0 (0) | 0 (0) | 5 (9.8) | 2 (11.8) | 0.229 |
RSV | 26 (19.4) | 21 (35.0) | 3 (6.5) | 2 (9.1) | 14 (27.5) | 0 (0) | 0.001 |
AdV | 3 (2.2) | 3 (5.0) | 0 (0) | 5 (22.7) | 0 (0) | 1 (5.9) | < 0.001 |
HRV | 2 (1.5) | 1 (1.7) | 0 (0) | 4 (18.2) | 0 (0) | 0 (0) | < 0.001 |
PIV | 9 (6.7) | 6 (10.0) | 0 (0) | 3 (13.6) | 3 (5.9) | 4 (23.5) | 0.035 |
Viral-PCP co-infection | 30 (22.4) | 3 (5.0) | 24 (52.2) | 3 (13.6) | 9 (17.6) | 4 (23.5) | < 0.001 |
Viral-aspergillus co-infection | 13 (9.7) | 17 (28.3) | 5 (10.9) | 1 (4.5) | 6 (11.8) | 2 (11.8) | 0.010 |
Viral-bacteria co-infection | 16 (11.9) | 12 (20.0) | 6 (13.0) | 1 (4.5) | 2 (3.9) | 3 (17.6) | 0.134 |
Viral-atypical co-infection | 4 (3.0) | 2 (3.3) | 3 (6.5) | 1 (4.5) | 0 (0) | 0 (0) | 0.518 |
Nosocomial bacterial infection | 26 (19.4) | 25 (41.7) | 12 (26.1) | 5 (22.7) | 11 (21.6) | 2 (11.8) | 0.021 |
Complications, n (%) | |||||||
 NIV | 41 (30.6) | 8 (13.3) | 17 (37.0) | 4 (18.2) | 15 (29.4) | 2 (11.8) | 0.035 |
 IMV | 41 (30.6) | 9 (15.0) | 12 (26.1) | 3 (13.6) | 17 (33.3) | 1 (5.9) | 0.033 |
 Respiratory failure | 78 (58.2) | 21 (35.0) | 24 (52.2) | 6 (27.3) | 28 (54.9) | 6 (35.3) | 0.004 |
 ICU care | 66 (49.3) | 10 (16.7) | 28 (60.9) | 8 (36.4) | 25 (49.0) | 2 (11.8) | < 0.001 |
 Septic shock | 31 (23.1) | 12 (20.0) | 17 (37.0) | 3 (13.6) | 11 (21.6) | 5 (29.4) | 0.256 |
 ECMO | 8 (6.0) | 4 (6.7) | 3 (6.5) | 1 (4.5) | 7 (13.7) | 0 (0) | 0.297 |
 In-hospital mortality | 40 (30.0) | 6 (10.0) | 18 (39.1) | 3 (13.6) | 13 (25.5) | 4 (23.5) | 0.011 |