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Table 1 The distribution of serotypes and clinical characteristics in patients with invasive pneumococcal disease (IPD) caused by the 24 most prevalent serotypes in Southwest Sweden between 2009 and 2015

From: Invasive pneumococcal disease in persons with predisposing factors is dominated by non-vaccine serotypes in Southwest Sweden

   Clinical characteristics
Serotype Number of strains, n (%) Median age (y) Predisposing factorsa, n (%) Meningitis#, n (%) Pneumonia#, n (%) Bacteremia with unknown focus, n (%) Other manifestationb, n (%) Admitted to the intensive care unit, n (%) Case fatality ratec, n (%)
22F 135 (10) 70 112 (83) 10 (7) 92 (68) 17 (13) 16 (12)* 30 (22) 17 (13)
3 128 (10) 68 99 (77) 15 (12) 100 (78) 8 (6)* 5 (4) 46 (36)*** 23 (18)
7F 99 (8) 60*** 65 (66)*** 4 (4) 84 (85)** 5 (5)** 7 (7) 17 (17) 4 (4)**
9 V 68 (5) 65 54 (79) 2 (3) 59 (87)** 4 (6) 3 (4) 16 (24) 4 (6)
14 67 (5) 75 53 (79) 4 (6) 60 (90)*** 2 (3)** 1 (2) 16 (24) 9 (13)
33F 59 (5) 67 49 (83) 7 (12) 35 (59)* 13 (22)* 4 (7) 12 (20) 5 (8)
4 57 (4) 64 47 (83) 2 (4) 49 (86)* 4 (7) 3 (5) 20 (36)* 4 (7)
19A 53 (4) 75* 43 (81) 3 (6) 39 (74) 9 (17) 2 (4) 16 (30) 10 (19)
11A 49 (4) 70 45 (92)* 4 (8) 35 (71) 7 (14) 4 (8) 14 (29) 10 (20)
9 N 47 (4) 71 42 (89) 1 (2) 38 (81) 5 (11) 4 (9) 7 (15) 4 (9)
8 43 (3) 66 35 (81) 2 (5) 34 (79) 4 (9) 3 (7) 4 (9)* 2 (5)
6A 42 (3) 74 33 (79) 2 (5) 29 (69) 9 (21) 2 (5) 11 (26) 6 (14)
23F 36 (3) 70 29 (81) 1 (3) 23 (64) 5 (14) 6 (17)* 4 (11) 2 (6)
23A 35 (3) 75 30 (86) 5 (14) 20 (57) 6 (17) 4 (11) 6 (17) 5 (14)
6B 34 (3) 75 29 (85) 4 (12) 27 (79) 3 (9) 0 (0) 6 (18) 7 (21)
1 32 (2) 49*** 18 (56)** 1 (3) 30 (94)** 1 (3) 0 (0) 2 (6)* 1 (3)
18C 27 (2) 66 20 (74) 5 (19) 17 (63) 3 (11) 2 (7) 6 (22) 2 (7)
35F 26 (2) 73 24 (92) 1 (4) 18 (69) 7 (27) 0 (0) 4 (15) 4 (15)
23B 26 (2) 75 19 (73) 4 (15) 8 (31)*** 10 (39)** 4 (15) 9 (35) 3 (12)
6C 25 (2) 82** 20 (80) 0 (0) 20 (80) 4 (16) 1 (4) 5 (20) 4 (16)
19F 25 (2) 68 20 (80) 3 (12) 16 (64) 5 (20) 1 (4) 7 (28) 5 (20)
12F 24 (2) 70 17 (71) 3 (13) 14 (58) 3 (13) 4 (17) 6 (25) 3 (13)
10A 24 (2) 72 23 (96) 3 (13) 12 (50)* 6 (25) 3 (13) 6 (25) 6 (25)
15C 20 (2) 68 15 (75) 5 (25)* 8 (40)** 7 (35)* 0 (0) 5 (25) 3 (15)
Other d 123 (9) 71 110 (89) 12 (10) 76 (62) 26 (21) 11 (9) 30 (24) 22 (18)
Total 1304 69 1051 (81) 102 (8) 943 (72) 173 (13) 90 (7) 302(23) 165 (13)
  1. * p < 0.05, ** p < 0.01, *** p < 0.001; versus total
  2. # There were five episodes of both pneumonia and meningitis. These were included in the analysis of each of the manifestations
  3. a Smoking, cardiovascular disease, malignancy, pulmonary disease, diabetes mellitus, immunosuppressive treatment, substance abuse, autoimmunity, liver disease, immune deficiency, renal disease and asplenia
  4. bAbscess, appendicitis, bronchitis, cholangitis, endocarditis, epidural abscess, epiglottitis, mastoiditis, osteitis, otitis media, pharyngitis, peritonitis, prosthetic joint infection, septic arthritis, skin and soft tissue infection, sinusitis and uteritis
  5. cDeath within 30 days of positive culture for pneumococci
  6. dIncluding serotype 15B (n = 19), 35B (n = 17), 16F (n = 13), 31 (n = 11), 15A (n = 11), 38 (n = 10), 24F (n = 9), 20 (n = 7), 17F (n = 6), 10B (n = 3), 34 (n = 3), Not typable (n = 3), 18A (n = 2), 7C (n = 2), 35A (n = 1), 9A (n = 1), 23 (n = 1), 9 (n = 1), 21 (n = 1), 11 (n = 1) and 5 (n = 1)