Table 3 Multivariable Cox regression model for mortality due to infection during 2004–2015 in entire cohort
Variable | Multivariable model | P-value |
|---|---|---|
HR (95% CI) | ||
Anemia (vs non-anemic group, model 1) | 1.47 (1.33, 1.64) | < 0.001 |
Subgroup analysis (model 2) | ||
Non-anemic group | 1 | |
Mild anemia (n = 36,383, 7.1%) | 1.38 (1.23, 1.55) | < 0.001 |
Moderate anemia (n = 11,787, 2.3%) | 2.02 (1.62, 2.50) | < 0.001 |
Severe anemia (n = 872, 0.2%) | 1.55 (0.50, 4.82) | 0.448 |
Age, year | 1.16 (1.15, 1.37) | < 0.001 |
Sex, male | 2.16 (1.96, 2.39) | < 0.001 |
Residence at diagnosis of sepsis | ||
Seoul (Capital city) | 1 | |
Other metropolitan city | 1.18 (1.02, 1.37) | 0.027 |
Other area | 1.24 (1.08, 1.41) | 0.002 |
Body mass index, kg/m2 | ||
18.5–24.9 (normal) | 1 | |
Below 18.5 (Underweight) | 2.33 (2.04, 2.66) | < 0.001 |
25.0–29.9 (Overweight) | 0.74 (0.67, 0.81) | < 0.001 |
Above 30.0 (Obese) | 1.07 (0.83, 1.37) | 0.625 |
Unknwon | 0.33 (0.05, 2.36) | 0.270 |
Annual income level | ||
0–20% | 1 | |
20–40% | 0.91 (0.80, 1.03) | 0.143 |
40–60% | 0.84 (0.74, 0.96) | 0.008 |
60–80% | 0.74 (0.65, 0.83) | < 0.001 |
80–100% | 0.65 (0.58, 0.73) | < 0.001 |
Underlying disability | ||
Mild to moderate | 1.19 (0.88, 1.59) | 0.258 |
Severe | 1.63 (1.12, 2.37) | 0.011 |
Smoking status | ||
Never smoker | 1 | |
Previous smoker | 1.34 (1.16, 1.54) | < 0.001 |
Current smoker | 1.50 (1.35, 1.67) | < 0.001 |
Unknown | 1.08 (0.83, 1.39) | 0.580 |
Alcohol consumption (frequency) | ||
No drink | 1 | |
2–3 per a month | 0.73 (0.63, 0.85) | < 0.001 |
1–2 per a week | 0.91 (0.80, 1.05) | 0.199 |
3–4 per a week | 0.82 (0.69, 0.99) | 0.034 |
Almost everyday drink | 1.01 (0.87, 1.18) | 0.867 |
Unknown | 0.93 (0.66, 1.31) | 0.688 |
Exercise frequency | ||
No exercise | 1 | |
1–2 per a week | 0.81 (0.71, 0.92) | 0.001 |
3–4 per a week | 0.74 (0.61, 0.89) | 0.002 |
5–6 per a week | 0.72 (0.52, 0.99) | 0.044 |
Almost everyday | 0.79 (0.68, 0.92) | 0.002 |
Unknown | 1.22 (0.95, 1.58) | 0.128 |
Charlson comorbidity index, 1 point (model 2) | 1.13 (1.11, 1.15) | < 0.001 |
Myocardial infarction | 1.19 (0.91, 1.55) | 0.198 |
Congestive heart failure | 1.18 (1.01, 1.3) | 0.038 |
Peripheral vascular disease | 1.22 (1.06, 1.40) | 0.007 |
Cerebrovascular disease | 1.29 (1.13, 1.47) | < 0.001 |
Dementia | 1.48 (1.07, 2.04) | 0.018 |
Chronic pulmonary disease | 1.26 (1.15, 1.37) | < 0.001 |
Rheumatic disease | 1.29 (1.13, 1.47) | < 0.001 |
Peptic ulcer disease | 0.91 (0.83, 0.99) | 0.028 |
Mild liver disease | 1.24 (1.13, 1.37) | < 0.001 |
Diabetes without chronic complication | 1.25 (1.10, 1.43) | 0.001 |
Diabetes with chronic complication | 1.36 (1.16, 1.59) | < 0.001 |
Hemiplegia or paraplegia | 1.13 (0.79, 1.64) | 0.503 |
Renal disease | 0.92 (0.60, 1.40) | 0.692 |
Any malignancy | 1.15 (1.03, 1.28) | 0.014 |
Moderate or severe liver disease | 2.30 (1.55, 3.43) | < 0.001 |
Metastatic solid tumour | 0.66 (0.37, 1.18) | 0.162 |
AIDS/HIV | 0.00 (0.00-) | 0.997 |