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Table 1 Characteristics at admission of the patients with COVID-19

From: Lymphocyte subset alterations with disease severity, imaging manifestation, and delayed hospitalization in COVID-19 patients

Variable

Total (n = 106)

Mild (n = 73)

Severe (n = 33)

Univariate logistic regression

Multivariate logistic regression

HR (95% CI)

P

HR (95% CI)

P

Epidemiological and clinical characteristics

Age (years)

46.17 ± 14.39

44.95 ± 13.59

48.88 ± 15.88

1.020 (0.990–1.050)

0.194

  

Gender (female/male)

42/64

31/42

11/22

1.476 (0.625–3.488)

0.375

  

Time from onset to hospitalization (d)

5 (2–8)

4 (2–7)

7 (4–10)

1.156 (1.034–1.293)

0.011

  

Exposure history(Y/N)

83 (78.3%)

55 (75.3%)

28 (84.8%)

1.833 (0.616–5.453)

0.276

  

Any comorbidities

33 (31.1%)

18 (24.7%)

15 (45.5%)

2.546 (1.069–6.063)

0.035

  

Hypertension

8 (7.5%)

4 (5.5%)

4 (12.1%)

2.379 (0.557–10.166)

0.242

  

Diabetes

10 (9.4%)

6 (8.2%)

4 (12.1%)

1.540 (0.404–5.871)

0.527

  

Hepatitis B

7 (6.6%)

6 (8.2%)

1 (30%)

0.349 (0.040–3.021)

0.339

  

Bacterial infection

12 (11.3%)

7 (9.6%)

5 (15.2%)

1.684 (0.492–5.759)

0.406

  

Signs and symptoms

Fever

97 (91.5%)

66 (90.4%)

31 (93.9%)

1.644 (0.323–8.377)

0.550

  

Dry cough

46 (43.4%)

30 (41.1%)

16 (48.5%)

1.349 (0.590–3.084)

0.478

  

Sputum production

12 (11.3%)

5 (6.8%)

7 (21.2%)

3.662 (1.067–12.570)

0.039

  

Chills

22 (20.8%)

17 (23.3%)

5 (15.2%)

0.588 (0.197–1.759)

0.342

  

Myalgia

8 (7.5%)

6 (8.2%)

2 (6.1%)

0.720 (0.138–3.774)

0.698

  

Chest tightness

34 (32.1%)

15 (20.5%)

19 (57.6%)

5.248 (2.147–12.827)

< 0.001

3.256 (1.134–9.345)

0.028

Polypnea

14 (13.2%)

4 (5.5%)

10 (30.3%)

7.500 (2.145–26.227)

0.002

  

Fatigue

21 (19.8%)

12 (16.4%)

9 (27.3%)

1.906 (0.712–5.104)

0.199

  

Headache/ dizziness

13 (12.3%)

12 (16.4%)

1 (3.0%)

0.159 (0.020–1.277)

0.084

  

Sore throat

20 (18.9%)

14 (19.2%)

6 (18.2%)

0.937 (0.325–2.701)

0.903

  

Rhinorrhea/ Rhinobyon

6 (5.7%)

5 (6.8%)

1 (3.0%)

0.425 (0.048–3.789)

0.443

  

Diarrhea

7 (6.6%)

4 (5.5%)

3 (9.1%)

1.725 (0.364–8.185)

0.493

  

Laboratory parameters

CRP (mg/L)

12.63 (3.53–40.49)

9.00 (2.46–24.93)

22.99 (6.36–77.01)

1.011 (1. 002–1.021)

0.018

  

WBC (×109/L)

5.14 (3.63–6.79)

4.84 (3.60–6.63)

5.68 (3.68–7.00)

1.076 (0.926–1.249)

0.339

  

Lymphocyte count (× 109/L)

0.99 (0.65–1.40)

1.13 (0.86–1.58)

0.68 (0.40–0.99)

0.065 (0.018–0.244)

< 0.001

0.097 (0.024–0.396)

0.010

Neutrophils count (× 109/L)

3.47 (2.30–5.17)

3.19 (2.07–4.89)

3.95 (2.66–5.95)

1.163 (0.996–1.357)

0.055

  

RBC (× 1012/L)

4.61 ± 0.55

4.66 ± 0.54

4.50 ± 0.57

0.571 (0.262–1.241)

0.157

  

Hemoglobin (g/L)

143.59 ± 16.91

144.29 ± 17.37

142.06 ± 16.02

0.992 (0. 969–1.016)

0.530

  

Platelets (× 109/L)

176.16 ± 62.11

181.53 ± 61.09

164.27 ± 63.65

0.995 (0. 987–1.003)

0.189

  

Albumin (g/L)

43.03 ± 6.07

44.32 ± 5.71

40.16 ± 5.94

0.857 (0.781–0.939)

0.001

  

ALT (U/L)

18.00 (12.00–34.00)

16.00 (12.00–30.50)

23.00 (16.00–43.00)

1.010 (0.996–1.025)

0.167

  

AST (U/L)

24.00 (19.00–33.00)

22.00 (18.00–28.50)

28.00 (22.00–36.50)

1.010 (0.994–1.027)

0.228

  

Total bilirubin (μmol/L)

9.05 (5.55–12.38)

7.70 (5.30–11.40)

9.60 (7.20–15.40)

1.054 (0.982–1.130)

0.143

  

Direct bilirubin (μmol/L)

2.60 (2.00–4.03)

2.50 (1.95–3.60)

3.60 (2.40–5.65)

1.198 (1.024–1.401)

0.024

  

GGT (U/L)

24.00 (14.00–47.50)

20.00 (12.00–34.00)

41.00 (22.00–71.50)

1.011 (1.001–1.022)

0.034

1.011 (1.002–1.021)

0.022

Lactate dehydrogenase

231.50 (190.75–320.25)

211.00 (183.50–269.50)

291.00 (239.50–394.50)

1.008 (1.004–1.013)

0.001

  

Creatinine (mmol/L)

65.20 (52.00–79.90)

65.70 (51.85–79.50)

63.60 (52.70–81.58)

1.004 (0.987–1.020)

0.668

  

Urea nitrogen (mmol/L)

4.20 (3.40–5.35)

4.10 (3.30–5.30)

4.55 (3.53–5.50)

1.068 (0.879–1.298)

0.507

  

Creatine kinase (U/L)

85.00 (59.25–125.00)

85.00 (60.00–124.50)

97.00 (51.00–134.00)

1.003 (0.998–1.007)

0.270

  

CK-MB (U/L)

13.00 (10.00–16.00)

13.00 (10.00–15.00)

13.00 (10.00–19.00)

1.017 (0.985–1.050)

0.297

  

Prothrombin time (s)

12.30 (11.90–12.85)

12.25 (11.83–12.70)

12.40 (12.10–13.15)

1.247 (0.769–2.022)

0.371

  

Thrombin time (s)

15.50 (14.95–16.40)

15.60 (15.10–16.65)

15.30 (14.65–16.15)

0.975 (0.707–1.344)

0.877

  

APTT (s)

29.30 (27.25–32.95)

29.20 (27.13–32.38)

30.30 (27.80–33.75)

1.004 (0.951–1.060)

0.879

  

D-dimer (mg/L)

0.29 (0.19–0.57)

0.25 (0.16–0.50)

0.49 (0.27–1.03)

3.883 (1.485–10.151)

0.006

  
  1. Abbreviations: CRP C-reactive protein, WBC white blood cell count, RBC red blood cell count, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT γ-glutamyl transpeptidase, APTT activated partial thromboplastin time