Variable | Total (n = 106) | Mild (n = 73) | Severe (n = 33) | Univariate logistic regression | Multivariate logistic regression | ||
---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | ||||
Epidemiological and clinical characteristics | |||||||
Age (years) | 46.17 ± 14.39 | 44.95 ± 13.59 | 48.88 ± 15.88 | 1.020 (0.990–1.050) | 0.194 | ||
Gender (female/male) | 42/64 | 31/42 | 11/22 | 1.476 (0.625–3.488) | 0.375 | ||
Time from onset to hospitalization (d) | 5 (2–8) | 4 (2–7) | 7 (4–10) | 1.156 (1.034–1.293) | 0.011 | ||
Exposure history(Y/N) | 83 (78.3%) | 55 (75.3%) | 28 (84.8%) | 1.833 (0.616–5.453) | 0.276 | ||
Any comorbidities | 33 (31.1%) | 18 (24.7%) | 15 (45.5%) | 2.546 (1.069–6.063) | 0.035 | ||
Hypertension | 8 (7.5%) | 4 (5.5%) | 4 (12.1%) | 2.379 (0.557–10.166) | 0.242 | ||
Diabetes | 10 (9.4%) | 6 (8.2%) | 4 (12.1%) | 1.540 (0.404–5.871) | 0.527 | ||
Hepatitis B | 7 (6.6%) | 6 (8.2%) | 1 (30%) | 0.349 (0.040–3.021) | 0.339 | ||
Bacterial infection | 12 (11.3%) | 7 (9.6%) | 5 (15.2%) | 1.684 (0.492–5.759) | 0.406 | ||
Signs and symptoms | |||||||
Fever | 97 (91.5%) | 66 (90.4%) | 31 (93.9%) | 1.644 (0.323–8.377) | 0.550 | ||
Dry cough | 46 (43.4%) | 30 (41.1%) | 16 (48.5%) | 1.349 (0.590–3.084) | 0.478 | ||
Sputum production | 12 (11.3%) | 5 (6.8%) | 7 (21.2%) | 3.662 (1.067–12.570) | 0.039 | ||
Chills | 22 (20.8%) | 17 (23.3%) | 5 (15.2%) | 0.588 (0.197–1.759) | 0.342 | ||
Myalgia | 8 (7.5%) | 6 (8.2%) | 2 (6.1%) | 0.720 (0.138–3.774) | 0.698 | ||
Chest tightness | 34 (32.1%) | 15 (20.5%) | 19 (57.6%) | 5.248 (2.147–12.827) | < 0.001 | 3.256 (1.134–9.345) | 0.028 |
Polypnea | 14 (13.2%) | 4 (5.5%) | 10 (30.3%) | 7.500 (2.145–26.227) | 0.002 | ||
Fatigue | 21 (19.8%) | 12 (16.4%) | 9 (27.3%) | 1.906 (0.712–5.104) | 0.199 | ||
Headache/ dizziness | 13 (12.3%) | 12 (16.4%) | 1 (3.0%) | 0.159 (0.020–1.277) | 0.084 | ||
Sore throat | 20 (18.9%) | 14 (19.2%) | 6 (18.2%) | 0.937 (0.325–2.701) | 0.903 | ||
Rhinorrhea/ Rhinobyon | 6 (5.7%) | 5 (6.8%) | 1 (3.0%) | 0.425 (0.048–3.789) | 0.443 | ||
Diarrhea | 7 (6.6%) | 4 (5.5%) | 3 (9.1%) | 1.725 (0.364–8.185) | 0.493 | ||
Laboratory parameters | |||||||
CRP (mg/L) | 12.63 (3.53–40.49) | 9.00 (2.46–24.93) | 22.99 (6.36–77.01) | 1.011 (1. 002–1.021) | 0.018 | ||
WBC (×109/L) | 5.14 (3.63–6.79) | 4.84 (3.60–6.63) | 5.68 (3.68–7.00) | 1.076 (0.926–1.249) | 0.339 | ||
Lymphocyte count (× 109/L) | 0.99 (0.65–1.40) | 1.13 (0.86–1.58) | 0.68 (0.40–0.99) | 0.065 (0.018–0.244) | < 0.001 | 0.097 (0.024–0.396) | 0.010 |
Neutrophils count (× 109/L) | 3.47 (2.30–5.17) | 3.19 (2.07–4.89) | 3.95 (2.66–5.95) | 1.163 (0.996–1.357) | 0.055 | ||
RBC (× 1012/L) | 4.61 ± 0.55 | 4.66 ± 0.54 | 4.50 ± 0.57 | 0.571 (0.262–1.241) | 0.157 | ||
Hemoglobin (g/L) | 143.59 ± 16.91 | 144.29 ± 17.37 | 142.06 ± 16.02 | 0.992 (0. 969–1.016) | 0.530 | ||
Platelets (× 109/L) | 176.16 ± 62.11 | 181.53 ± 61.09 | 164.27 ± 63.65 | 0.995 (0. 987–1.003) | 0.189 | ||
Albumin (g/L) | 43.03 ± 6.07 | 44.32 ± 5.71 | 40.16 ± 5.94 | 0.857 (0.781–0.939) | 0.001 | ||
ALT (U/L) | 18.00 (12.00–34.00) | 16.00 (12.00–30.50) | 23.00 (16.00–43.00) | 1.010 (0.996–1.025) | 0.167 | ||
AST (U/L) | 24.00 (19.00–33.00) | 22.00 (18.00–28.50) | 28.00 (22.00–36.50) | 1.010 (0.994–1.027) | 0.228 | ||
Total bilirubin (μmol/L) | 9.05 (5.55–12.38) | 7.70 (5.30–11.40) | 9.60 (7.20–15.40) | 1.054 (0.982–1.130) | 0.143 | ||
Direct bilirubin (μmol/L) | 2.60 (2.00–4.03) | 2.50 (1.95–3.60) | 3.60 (2.40–5.65) | 1.198 (1.024–1.401) | 0.024 | ||
GGT (U/L) | 24.00 (14.00–47.50) | 20.00 (12.00–34.00) | 41.00 (22.00–71.50) | 1.011 (1.001–1.022) | 0.034 | 1.011 (1.002–1.021) | 0.022 |
Lactate dehydrogenase | 231.50 (190.75–320.25) | 211.00 (183.50–269.50) | 291.00 (239.50–394.50) | 1.008 (1.004–1.013) | 0.001 | ||
Creatinine (mmol/L) | 65.20 (52.00–79.90) | 65.70 (51.85–79.50) | 63.60 (52.70–81.58) | 1.004 (0.987–1.020) | 0.668 | ||
Urea nitrogen (mmol/L) | 4.20 (3.40–5.35) | 4.10 (3.30–5.30) | 4.55 (3.53–5.50) | 1.068 (0.879–1.298) | 0.507 | ||
Creatine kinase (U/L) | 85.00 (59.25–125.00) | 85.00 (60.00–124.50) | 97.00 (51.00–134.00) | 1.003 (0.998–1.007) | 0.270 | ||
CK-MB (U/L) | 13.00 (10.00–16.00) | 13.00 (10.00–15.00) | 13.00 (10.00–19.00) | 1.017 (0.985–1.050) | 0.297 | ||
Prothrombin time (s) | 12.30 (11.90–12.85) | 12.25 (11.83–12.70) | 12.40 (12.10–13.15) | 1.247 (0.769–2.022) | 0.371 | ||
Thrombin time (s) | 15.50 (14.95–16.40) | 15.60 (15.10–16.65) | 15.30 (14.65–16.15) | 0.975 (0.707–1.344) | 0.877 | ||
APTT (s) | 29.30 (27.25–32.95) | 29.20 (27.13–32.38) | 30.30 (27.80–33.75) | 1.004 (0.951–1.060) | 0.879 | ||
D-dimer (mg/L) | 0.29 (0.19–0.57) | 0.25 (0.16–0.50) | 0.49 (0.27–1.03) | 3.883 (1.485–10.151) | 0.006 |