Fig. 2
Comparison of frequencies of single TNF-α-, total TNF-α-, single IFN-γ-, total IFN-γ-, dual IFN-γ/TNF-α-secreting T cells following ESAT-6 or CFP-10 stimulation in ATB, LTBI and HC groups. T cell frequencies are estimated as per 2.5 × 105 PBMC. Each point represents a sample. (A) Frequencies of T cells secreting only TNF-α, without IFN-γ. (B) Frequencies of all the T cells secreting TNF-α, with or without IFN-γ secretion. (C) Frequencies of T cells secreting only IFN-γ, without TNF-α. (D) Frequencies of all the T cells secreting IFN-γ, with or without TNF-α secretion. (E) Frequencies of T cells secreting both IFN-γ and TNF-α simultaneously. Abbreviations: ATB, Active tuberculosis; LTBI, latent tuberculosis infection; HC, healthy control; MTB, mycobacterium.tuberculosis. ***P < 0.001, **P < 0.01