Table 1 Characteristics and outcomes among different groups
From: Management of enterococcal central line-associated bloodstream infections in patients with cancer
Variables | CLABSI with MBI (G1) | CRBSI and CLABSI without MBI (G2) | Non-CLABSI (G3) | P-value | Pairwise comparisons with significant differences |
|---|---|---|---|---|---|
(n = 132) | (n = 101) | (n = 164) | |||
N (%) | N (%) | N (%) | |||
Age (years), median (range) | 58 (19–89) | 57 (10–87) | 58 (18–82) | 0.95 | |
Sex, male | 90 (68) | 64 (63) | 91 (55) | 0.08 | |
Type of cancer | < .0001 | G1 vs G2:P < .0001; G1 vs G3: P < .0001 | |||
Hematologic malignancy a | 130 (98) | 80 (79) | 117 (71) | ||
Solid tumor | 2 (2) | 21 (21) | 47 (29) | ||
Transplant | 49 (37) | 45 (45) | 37/163 (23) | <.001 | G1 vs G3: P = 0.007; G2 vs G3: P < .001 |
Allogenienc | 46/49 (94) | 42/45 (93) | 33/37 (89) | ||
Autologous | 3/49 (6) | 3/45 (7) | 4/37 (11) | ||
Neutropenia (ANC < 500 cells/microL) | 127 (96) | 15 (15) | 85 (52) | < .0001 | G1 vs G2: P < .0001; G1 vs G3: P < .0001; G2 vs G3: P < .0001 |
Admission to the Intensive Care Unit at bacteremia onset | 27 (20) | 26 (26) | 28 (17) | 0.24 | |
Graft versus host disease at bacteremia onset | 6/131 (5) | 6 (6) | 10/159 (6) | 0.81 | |
Colonization with Vancomycin Resistant Enterococci (VRE) at bacteremia onset | 48/122 (39) | 21/80 (26) | 42/124 (34) | 0.16 | |
Enterococcus species | |||||
E. faecalis | 41 (31) | 63 (62) | 75 (46) | < .0001 | G1 vs G2; P < .0001; G1 vs G3: P = .01; G2 vs G3: P = .01 |
E. faecium | 85 (64) | 37 (37) | 78 (48) | < .0001 | G1 vs G2: P < .0001; G1 vs G3: P = .004 |
Other Enterococcus species b | 6 (5) | 1 (1) | 11 (7) | 0.09 | |
VRE isolate | 56/131 (43) | 29/100 (29) | 48 (29) | 0.027 | G1 vs G3: P = .016; |
Days between cvc insertion and positive culture, median (IQR) | 30 (16–91) | 61 (17–125) | 55 (21–177) | 0.007 | G1 vs G3: P = .002 |
Catheter management | 0.004 | G2 vs G3: P < .001 | |||
Removal | 64 (48) | 56 (55) | 59 (36) | ||
Lock therapy | 2 (2) | 3 (3) | 1 (1) | ||
Catheter retained (without lock therapy) | 66 (50) | 42 (42) | 104 (63) | ||
Catheter removal since positive blood culture c | 0.008 | G2 vs G3: P = .003 | |||
< 3 days | 29/130 (22) | 32/98 (33) | 32/163 (20) | ||
3–7 days | 31/130 (24) | 22/98 (22) | 23/163 (14) | ||
> 7 days (including catheter retained) | 70/130 (54) | 44/98 (45) | 108/163 (66) | ||
Received Antibiotics | 125 (95) | 96 (95) | 149 (91) | 0.30 | |
Duration of antibiotic therapy (days), median (IQR) | 16 (11–22) | 15 (9–18) | 15 (10–22) | 0.53 | |
Complications within 3 months | 7/130 (5) | 8/98 (8) | 6/155 (4) | 0.34 | |
All-cause mortality within 3 months | 67 (51) | 39 (39) | 71 (43) | 0.17 | |
Infection-related mortality within 3 months | 16/131 (12) | 8/97 (8) | 13/158 (8) | 0.45 | |
Recurrence within 3 months since microbiologic resolution d | 10/111 (9) | 6/88 (7) | 11/137 (8) | 0.85 | |