Table 1 The characteristics and immunological profiles of the patients with and without antibody response
From: Immune cell profiling and antibody responses in patients with COVID-19
Variables | IgM antibody | IgG antibody | ||||
|---|---|---|---|---|---|---|
Non-responders (n = 14) Median (IQR) | Responders (n = 39) Median (IQR) | P value | Non-responders (n = 13) Median (IQR) | Responders (n = 40) Median (IQR) | P value | |
Age (year) | 54 (33–68) | 54 (39–60) | 0. 82 | 59 (42–76) | 53 (39–60) | 0.94 |
Days after onset of symptom | 9 (5–13) | 14 (11–18) | 0.036 | 10 (6–14) | 14 (10–18) | 0.23 |
Erythrocyte sedimentation rate (mm/h) | 35 (25–72) | 48 (35–69) | 0.49 | 36 (26–73) | 48 (34–69) | 0.45 |
C-reactive protein (mg/L) | 18 (14–40) | 31.5 (19–42) | 0.22 | 17 (7–34) | 31.5 (19–41) | 0.18 |
Interleukin 6 (pg/mL) | 11.3 (8–15) | 10 (6–16) | 0.2 | 11 (8–15) | 10 (6–16) | 0.32 |
White blood cell count (× 106 cells / L) | 10,980 (6928–15,000) | 7030 (5220–9980) | 0.1 | 10,860 (7150–17,075) | 7000 (5230–1024) | 0.17 |
Neutrophil count (× 106 cells / L) | 6865 (5498–10,691) | 4370 (2871–660) | 0.024 | 7700 (5259–11,625) | 4284 (2659–6840) | 0.046 |
Lymphocyte count (× 106 cells / L) | 1878 (1160–2344) | 1681 (1320–2000) | 0.3 | 1776 (1042–2098) | 1715 (1320–2131) | 0.47 |
Total T cell counts (CD3+) | 1148 (627–1465) | 1003 (739–1370) | 0.69 | 1019 (391–1305) | 1100.5 (785–1412) | 0.94 |
CD4+ T cell counts | 685.5 (283–872) | 663 (399–876) | 0.82 | 580 (249–787) | 693.5 (463–902) | 0.23 |
CD8+ T cell counts | 343 (216–449) | 280 (180–420) | 0.3 | 294 (117–451) | 291 (193–417) | 0.93 |
B cells (CD19+) counts | 230 (125–418) | 164.5 (105–237) | 0.35 | 195.5 (107–303) | 171.5 (110–243) | 0.74 |
B cells (CD20+) counts | 227.5 (126–398) | 159.5 (104–234) | 0.12 | 200 (109–288) | 165 (109–242) | 0.74 |
NK cell counts | 136 (79–318) | 151 (127–263) | 0.95 | 135 (68–244) | 158.5 (130–282) | 0.69 |
Neutrophil to lymphocyte ratio | 4.6 (2.2–9.6) | 2.4 (1.2–4.1) | 0.31 | 4.8 (2.5–9.9) | 2.3 (1.3–4.1) | 0.17 |