Table 1 Clinical characteristics of patients in both groups, univariable analysis and multivariable analysis: factors associated with multicentric lesions
Characteristics | The multicentric lesions group, N = 307 | The single CIN group, N = 1643 | Univariable analyses OR (95% CI) | Multivariable analyses OR (95% CI) | |
|---|---|---|---|---|---|
Age, median (Q1-Q3) | 50 (43–55.5) | 43 (36–50) | |||
Menopause, n (%) | Yes | 158 (51.5) | 460 (28.0) | 2.73 (2.13–3.50) | 3.14 (2.24–4.41) |
No | 149 (48.5) | 1183 (72.0) | |||
Smoking, n (%) | Yes | 8 (2.6) | 29 (1.8) | 1.49 (0.67–3.29) | 1.74 (0.59–5.14) |
No | 299 (97.4) | 1614 (98.2) | |||
Gravidity, n (%) | ≤2 | 126 (41.0) | 621 (37.8) | 1.15 (0.89–1.47) | 1.32 (0.92–1.90) |
≥3 | 181 (59.0) | 1022 (62.2) | |||
Parity, n (%) | ≤2 | 285 (92.8) | 1531 (93.2) | 0.95 (0.59–1.52) | 0.92 (0.47–1.80) |
≥3 | 22 (7.2) | 112 (6.8) | |||
A history of malignant tumor beyond the lower genital tract, n (%) | Yes | 10 (3.3) | 12 (0.7) | 4.58 (1.96–10.69) | 9.58(1.02–89.84) |
No | 297 (96.7) | 1631 (99.3) | |||
Cytology, n (%) | Abnormal | 184 (68.9) | 833 (62.5) | 0.75 (0.57–1.00) | |
Normal | 83 (31.1) | 499 (37.5) | |||
HPV test, n (%) | Positive | 294 (97.0) | 1391 (94.1) | 2.07 (1.03–4.15) | |
Negative | 9 (3.0) | 88 (5.9) | |||
Multiple HPV infection, n (%) | Yes | 65 (36.5) | 223 (27.2) | 1.54 (1.09–2.17) | 1.47(1.03–2.10) |
No | 113 (63.5) | 597 (72.8) | |||
HR-HPV viral load, median (IQR) | 272.165 (1118.17) | 10.13 (16.70) | |||
HR-HPV viral load, n (%) | >1000 | 27 (26.5) | 64 (17.0) | 1.76 (1.05–2.95) | |
≤1000 | 75 (73.5) | 313 (83.0) | |||