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Table 1 Clinical characteristics of patients in both groups, univariable analysis and multivariable analysis: factors associated with multicentric lesions

From: Human papillomavirus genotypes and the risk factors associated with multicentric intraepithelial lesions of the lower genital tract: a retrospective study

Characteristics The multicentric lesions group, N = 307 The single CIN group, N = 1643 Univariable analyses OR (95% CI) Multivariable analyses OR (95% CI)
Age, median (Q1-Q3)   50 (43–55.5) 43 (36–50)   
Menopause, n (%) Yes 158 (51.5) 460 (28.0) 2.73 (2.13–3.50) 3.14 (2.24–4.41)
No 149 (48.5) 1183 (72.0)   
Smoking, n (%) Yes 8 (2.6) 29 (1.8) 1.49 (0.67–3.29) 1.74 (0.59–5.14)
No 299 (97.4) 1614 (98.2)   
Gravidity, n (%) ≤2 126 (41.0) 621 (37.8) 1.15 (0.89–1.47) 1.32 (0.92–1.90)
≥3 181 (59.0) 1022 (62.2)   
Parity, n (%) ≤2 285 (92.8) 1531 (93.2) 0.95 (0.59–1.52) 0.92 (0.47–1.80)
≥3 22 (7.2) 112 (6.8)   
A history of malignant tumor beyond the lower genital tract, n (%) Yes 10 (3.3) 12 (0.7) 4.58 (1.96–10.69) 9.58(1.02–89.84)
No 297 (96.7) 1631 (99.3)   
Cytology, n (%) Abnormal 184 (68.9) 833 (62.5) 0.75 (0.57–1.00)  
Normal 83 (31.1) 499 (37.5)   
HPV test, n (%) Positive 294 (97.0) 1391 (94.1) 2.07 (1.03–4.15)  
Negative 9 (3.0) 88 (5.9)   
Multiple HPV infection, n (%) Yes 65 (36.5) 223 (27.2) 1.54 (1.09–2.17) 1.47(1.03–2.10)
No 113 (63.5) 597 (72.8)   
HR-HPV viral load, median (IQR)   272.165 (1118.17) 10.13 (16.70)   
HR-HPV viral load, n (%) >1000 27 (26.5) 64 (17.0) 1.76 (1.05–2.95)  
≤1000 75 (73.5) 313 (83.0)   
  1. CIN cervical intraepithelial neoplasia, SD standard deviation, HPV human papillomavirus, HR-HPV high-risk human papillomavirus, OR odds ratio, CI confidence interval, IQR Interquartile range