Table 2 Data collection and measurements for study participants. Cases and tick-bite controls

Written information and informed consent

X

Baseline characteristics

X

Physical examination

X^a

X^a

Recording of clinical manifestation, treatment and concomitant medication

X

X

X

X

X

Recording of adverse events

X

X

 General laboratory measurements

X

X^b

X^{b, c}

 Cultures - TBPs

X^d

 Multiplex qPCR - TBPs

X

X

X^c

 C6 EIA and confirmatory immunoblot – Borrelia burgdorferi s.l.

X

X

X^c

 ELISA and confirmatory VNT - TBEV

X

X

X^c

 IFA – Anaplasma phagocytophilum, Babesia microti, Rickettsia SFG

X

X

X^c

 Immunofluorescence protein microarray – Borrelia miyamotoi

X

X

X^c

 Comorbidities and pre-existent symptoms

X

X

X

X

X

 Somatic symptoms

X

X

X

X

X

 Pain, physical and social functioning: SF-36

X

X

X

X

X

 Relevant medical information from the treating physician

X