Skip to main content

Table 2 Data collection and measurements for study participants. Cases and tick-bite controls

From: Ticking on Pandora’s box: a prospective case-control study into ‘other’ tick-borne diseases

  Baseline 4 weeks 3 months 6 months 9 months 12 months
Written information and informed consent X      
Baseline characteristics X      
Physical examination Xa Xa     
Recording of clinical manifestation, treatment and concomitant medication X   X X X X
Recording of adverse events X   X    
Laboratory measurements
 General laboratory measurements X Xb Xb, c    
 Cultures - TBPs Xd      
 Multiplex qPCR - TBPs X X Xc    
 C6 EIA and confirmatory immunoblot – Borrelia burgdorferi s.l. X X Xc    
 ELISA and confirmatory VNT - TBEV X X Xc    
 IFA – Anaplasma phagocytophilum, Babesia microti, Rickettsia SFG X X Xc    
 Immunofluorescence protein microarray – Borrelia miyamotoi X X Xc    
Questionnaires
 Comorbidities and pre-existent symptoms X   X X X X
 Somatic symptoms X   X X X X
 Pain, physical and social functioning: SF-36 X   X X X X
 Relevant medical information from the treating physician   X     
  1. For explanation of abbreviations, see the main text
  2. aParticipants included through the outpatient department of infectious diseases of the Amsterdam UMC
  3. bGeneral laboratory measurements are repeated only at a consecutive time-point when deviating at baseline
  4. cLaboratory measurements are only performed when the third optional phlebotomy is performed
  5. dCultures are performed for participants meeting case criteria only