Table 2 Changes in CSF cytokine levels during therapy
Cytokine (pg/ml) | Baseline (n = 11) | Week 2 (n = 10) | Week 4 (n = 8) |
|---|---|---|---|
IL-1β | 0.10 (0.04,0.98) | 0.07 (0.04,0.17) | 0.11 (0.04,0.16) |
IL-2 | 0.16 (0.11,0.34) | 0.13 (0.12,0.16) | 0.14 (0.13,0.23) |
IL-4 | 0.09 (0.07,0.13) | 0.09 (0.06,0.14) | 0.09 (0.07,0.11) |
IL-5 | 0.90 (0.58,2.73) | 1.16 (0.73,1.42) | 2.74 (1.00,3.48) |
IL-6 | 43.8 (8.32,162) | 7.43 (3.89,17.4) | 27.8 (2.98,62.2) |
IL-7 | 0.05 (0.02,0.15) | 0.05 (0.03,0.06) | 0.07 (0.03,0.09) |
IL-10 | 2.56 (1.22,21.7) | 2.19 (1.33,3.87) | 2.26 (1.48,4.11) |
IL-12(p40) | 3.52 (2.89,4.37) | 2.89 (1.92,6.58) | 3.14 (2.13,5.47) |
IL-13 | 1.50 (1.22,2.89) | 1.33 (1.11,1.56) | 1.40 (1.24,2.35) |
IL-15 | 4.94 (2.19,7.69) | 4.54 (2.81,7.87) | 6.30 (2.84,11.2) |
IL-17A | 0.70 (0.44,0.83) | 0.38 (0.33,0.54) | 0.48 (0.31,0.77) |
IL-18 | 1.63 (1.04,4.91) | 2.40 (1.02,8.97) | 2.69 (1.07,11.9) |
IFN-γ | 0.64 (0.39,5.32) | 0.43 (0.32,0.73) | 0.46 (0.36,2.59) |
TNF-α | 20.6 (2.26,36.3) | 4.58 (3.11,19.5) | 5.81 (4.43,21.2) |
IL-8 | 36.7 (9.44,431) | 24.2 (22.8,73.8) | 39.7 (21.4,147) |
CXCL10 | 102 (4.16,791) | 315 (27.6,780) | 261 (24.0,1707) |
CCL2 | 1209 (629,5751) | 1079 (851,4060) | 2578 (846,5136) |
CCL3 | 0.26 (0.09,12.9) | 0.24 (0.08,4.68) | 0.32 (0.12,1.08) |
VEGF-A | 0.52 (0.44,0.55) | 0.48 (0.38,0.49) | 0.43 (0.29,0.46) |