Table 1 Baseline characteristics of the three groups
Parameters | HIV + CM+ (n = 12) | HIV + CM- (n = 6) | HIV-CM- (n = 17) | P value |
|---|---|---|---|---|
Demographics | ||||
Age (years) | 38.5 (34.5,46.5) | 41.5 (34.0,54.3) | 38.0 (28.5,49.5) | 0.689 |
female, n (%) | 2 (17) | 1 (17) | 12 (71) | 0.005 |
Laboratory exam | ||||
WBC count(×10^9/L) | 5.4 (3.4,9.0) | 4.8 (2.4,6.2) | 5.6 (4.5,6.5) | 0.543 |
Lymphocyte count (×10^9/L) | 0.5 (0.3,0.7) | 0.8 (0.6,1.1) | 2.0 (1.3,2.1) | < 0.001 |
Hemoglobin (HGB) (g/L) | 115 (76,133) | 124 (112,126) | 136 (130,144) | 0.003 |
Platelet count (×10^9/L) | 179 (116,247) | 214 (202,264) | 241 (170,279) | 0.187 |
ALT (U/L) | 31 (19,43) | 21 (13,30) | 20 (15,22) | 0.070 |
TBIL (μmol/L) | 9.7 (7.0,16.2) | 7.4 (3.9,9.6) | 9.8 (6.1,11.4) | 0.206 |
Albumin (g/L) | 32.1 (28.8,36.4) | 31.1 (28.9,33.0) | 42.2 (38.6,46.3) | < 0.001 |
Creatinine (μmol/L) | 57.9 (51.2,66.8) | 59.0 (43.5,68.3) | 58.0 (49.0,65.7) | 0.756 |
Serum potassium (mmol/L) | 4.0 (3.3,4.6) | 4.0 (3.7,4.3) | 4.0 (3.9,4.1) | 0.958 |
Serum sodium (mmol/L) | 135 (130,138) | 138 (136,140) | 139 (138,141) | 0.019 |
Serum chloride (mmol/L) | 102 (99,105) | 102 (98,105) | 105 (104,106) | 0.025 |
CD4+T-cell count (cells/μl) | 21 (8,36) | 27 (10,61) | 702 (515,878) | < 0.001 |
HIV load (log10 copies/ml) | 4.5 (4.1,4.8) | 4.9 (4.2,5.3) | – | 0.223 |
CSF parameters | ||||
ICP (mmH2O) | 220 (98,310) | 90 (75,135) | 110 (95,128) | 0.036 |
WBC count (×10^6/L) | 21.5 (3.3,91.8) | 1.5 (1.0,2.0) | 2.0 (1.0,3.0) | 0.002 |
Lymphocyte count (× 10^6/L) | 8.0 (1.8,35.3) | 1.0 (0.0,2.0) | 1.0 (1.0,2.0) | 0.001 |
Glucose (mmol/L) | 2.3 (1.7,3.3) | 3.1 (2.8,3.8) | 3.0 (2.9,3.3) | 0.060 |
Chlorine (mmol/L) | 122 (119,123) | 123 (120,128) | 125 (124,127) | 0.010 |
Total protein (mg/L) | 271.6 (112.0,355.1) | 172.3 (144.3,225.6) | 145.4 (114.5,182.0) | 0.111 |