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Table 4 Comparison of salivary gland and Leishmania gene expression levels (SP15 & LeIF) isolated from field-caught P. papatasi in three Bio-climate zones of Northern Khorasan province

From: Species diversity and spatial distribution of CL/VL vectors: assessing bioclimatic effect on expression plasticity of genes possessing vaccine properties isolated from wild-collected sand flies in endemic areas of Iran

Isolated source

Status

Climate ecotopes

Frequency of Distribution of Gene expression

P value (P < 0.05)MW

(A) Mediterraneanb

(B) Mountainousa

(C) Semi aridc

Mean ± SEM of All 14 sites Expression Fold

All 14 sites Expression Fold

(A)

(B)

(C)

A vs B

A vs C

B vs C

P. papatasi

Salivary protein SP15 (Fold Change)

Blood-Fed

Early (June)

7 out of 14d

1.20

0.32

1.67

1.40429 ± 0.382118

1.585 ± 0.419459

2.77571 ± 0.434103

0.6295N

0.0101S

0.0180S

0.96

0.54

3.14

0.42

0.49

2.23

1.70

1.94

2.12

0.20

1.73

2.85

0.56

2.92

5.63

2.80

3.89

3.88

Mid (Aug)

7 out of 14d

1.21

1.58

1.99

1.87071 ± 0.423889

2.095 ± 473,827

4.13571 ± 0.575062

0.7652N

0.0035S

0.0054S

0.31

0.29

3.88

0.65

0.57

2.81

1.77

2.10

2.70

3.23

3.42

3.50

0.53

0.85

6.31

3.83

4.40

7.37

Late (Sep)

7 out of 14d

1.79

1.92

2.30

3.91929 ± 1.00625

3.37286 ± 0.770445

6.70214 ± 1.44592

0.5972N

0.0115S

0.0030S

0.55

0.48

4.37

1.19

1.60

3.62

3.83

3.72

4.41

1.97

1.48

4.10

3.27

1.39

9.79

4.80

6.49

24.13

Leishmania parasite (P. papatasi)

LeIF (Fold Change)

Gravid

7 out of 14d

0.770

1.090

0.920

1.90557 ± 0.298908

1.55971 ± 0.164003

0.997929 ± 108,543

0.5502N

0.0101S

0.0123S

2.070

1.500

1.340

0.920

1.700

0.590

1.810

1.210

0.430

0.993

0.940

0.790

1.440

1.110

0.970

2.130

1.830

1.120

Semi-Gravid

7 out of 14d

0.460

0.820

0.410

1.63629 ± 0.230047

1.29536 ± 0.17331

0.956429 ± 159,147

0.3012N

0.0326S

0.1543N

1.530

1.720

1.360

0.670

0.560

0.600

0.980

0.850

0.530

2.070

1.640

0.840

2.910

0.990

1.470

2.414

2.210

1.320

Blood-Fed

7 out of 14d

0.210

0.16

0.11

0.577857 ± 0.119376

1.07714 ± 0.188427

0.355 ± 0.0988436

0.0596N

0.0886N

0.0035S

1.190

1.90

0.17

0.090

1.70

1.02

1.280

0.81

0.18

0.190

0.24

0.09

0.340

0.11

0.11

1.130

0.39

0.52

  1. a Bojnord, Shirvan, Garmeh, Faruj, and Esfarayen Counties
  2. b Raz-o Jargalan, and Maneh-o Samalqan Counties
  3. c Jajarm, southern parts of Garmeh and, western areas of Esfarayen Counties, SEM: Standard Error of Mean, MW, Mann-Whiteny U Test
  4. d The remaining 7 variables are shown in Supplementary 3, S: Significant, N: No significant
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BMC Infectious Diseases

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