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Table 1 Baseline demographic information, symptoms of COVID-19, comorbidity and laboratory findings in patients during admission

From: Impact of high dose of baricitinib in severe COVID-19 pneumonia: a prospective cohort study in Bangladesh

Variable

HD group (N = 122)

UD group

(N = 116)

P value

Male/female, n (%)

83/39 (68/32)

76/40 (66/34)

 

Age (year), median (IQR)

63 (54.8–69)

59 (54–68)

0.655

Onset of symptom-to-hospitalization time, median (IQR)

6 (6–8)

7 (6–8)

0.144

Fever (°F), median (IQR)

101 (100–101)

101 (100–101)

0.306

Dry cough, n (%)

122 (100)

116 (100)

 

Weakness, n (%)

122 (100)

116 (100)

 

Shortness of breath, n (%)

96 (78.7)

94 (81)

0.429

Anosmia, n (%)

79 (64.8)

88 (75.9)

0.029

Diarrhea, n (%)

68 (55.7)

57 (49.1)

0.001

Sore throat, n (%)

62 (50.8)

70 (60.3)

0.001

Diabetes, n (%)

95 (77.9)

88 (75.9)

0.392

Hypertension, n (%)

86 (70.5)

81 (69.8)

0.166

CVD, n (%)

55 (45.1)

47 (40.5)

0.001

Bronchial asthma, n (%)

43 (35.2)

36 (31)

0.001

CKD, n (%)

21 (17.2)

23 (19.8)

0.001

COPD, n (%)

17 (13.9)

14 (12.1)

0.001

Obesity, n (%)

15 (12.3)

14 (12.1)

0.001

PUD, n (%)

11 (9)

16 (13.8)

0.001

CLD, n (%)

6 (4.9)

8 (6.9)

0.001

Malignancy, n (%)

3 (2.5)

4 (3.4)

0.001

PD, n (%)

2 (1.6)

1 (0.9)

0.001

SpO2 (%), median (IQR)

90 (88–90.3)

90 (88–90)

0.628

RSO, median (IQR)

7 (4–11)

7 (4–10)

0.640

Respiratory rate, (breaths/min), median (IQR)

25 (21–26)

21 (19–25)

0.001

Heart rate (beat/min), median (IQR)

98 (85–106)

90 (85–102)

0.072

CRP (mg/L), median (IQR)

179 (76.9–263.5)

159 (44.5–231.4)

0.199

Procalcitonin (ng/mL), median (IQR)

1.04 (0.08–2.69)

0.9 (0.12–1.26)

0.001

WBC (K/μL), median (IQR)

9.5 (6.4–12.4)

9.2 (6.7–12.1)

0.915

Neutrophils (%), median (IQR)

86 (77.2–88.9)

86.3 (78.6–90.2)

0.110

Lymphocytes (%), median (IQR)

14.3 (11.5–16.5)

13.9 (10.8–16.4)

0.141

Platelet (K/μL), median (IQR)

188.5 (144.8–256)

215 (150.7–295.8)

0.327

D-dimer (mg /L FEU), median (IQR)

5.2 (3.9–6.8)

4.9 (2.6–6.3)

0.392

IL-6 (pg/mL), median (IQR)

47 (17.5–78)

45 (10.5–75.7)

0.153

Serum Ferritin (ng/mL), median (IQR)

605 (478–786)

641 (456–787.5)

0.144

LDH ((U/L), median (IQR)

489 (409–646.7)

474 (408.5–593)

0.088

Creatinine (mg/dL), median (IQR)

1.1 (0.8–1.9)

1.1 (0.7–1.7)

0.122

ALT (U/L), median (IQR)

58 (46–83)

56 (40.7–75.8)

0.485

AST (U/L), median (IQR)

36.5 (29–48)

35 (29–46)

0.011

MEWS, median (IQR)

3 (2–3)

3 (2–3)

0.001

  1. IQR Interquartile range, n Number, % Percentage, °F Grade Fahrenheit, CVD Cardiovascular disease, CKD Chronic kidney disease, COPD Chronic obstructive pulmonary disease, PUD Peptic ulcer disease, CLD Chronic liver disease, PD Parkinson’s disease, SpO2 Oxygen saturation in blood, min Minute, RSO Requirement of supplemental oxygen, CRP C-reactive protein, mg Milligram, L Liter, FEU Fibrinogen equivalent units, ng Nanogram, WBC White blood cells, K/μL Thousand cells per micro liter, IL Interleukin, pg/mL Picograms per milliliter, LDH Lactate dehydrogenase, U/L Units per liter, dL Deciliter, ALT Alanine aminotransferase, AST Aspartate aminotransferase, MEWS Modified Early Warning Score