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Table 3 Disease detection, colposcopies needed, and false positive (negative) rates of different triage strategies (N = 2731)

From: Triaging HPV-positive, cytology-negative cervical cancer screening results with extended HPV genotyping and p16INK4a immunostaining in China

Triage strategies Number of colposcopies CRR (%) Number of CIN2+/ CIN3+ detected NRND for CIN2+/CIN3+ FPR (%)
for CIN2+
FNR (%) for CIN2+
Single test
 1.p16+ 698 25.6 113/42 6.2/16.6 22.5 16.9
 2.HPV16+ 624 22.8 85/46 7.3/13.6 20.8 37.5
 3.HPV16/33+ 756 27.7 92/48 8.2/15.8 25.6 32.4
 4.HPV16/33/58+ 1094 40.1 106/50 10.3/21.9 38.1 22.1
 5.HPV16/33/58/31+ 1240 45.4 111/50 11.2/24.8 43.5 18.4
 6.HPV16/33/58/31/35+ 1301 47.6 113/50 11.5/26.0 45.8 16.9
7.HPV16/18 + (comparator) 888 32.5 93/49 9.5/18.1 30.6 31.6
 8.HPV16/18/31/33/45/52/58+ 1885 69.0 125/52 15.1/36.3 67.8 8.1
HPV types + or p16+
 9.HPV16+ or p16+ 1049 38.4 127/52 8.3/20.2 35.5 6.6
 10.HPV16/33+ or p16+ 1150 42.1 128/52 9.0/22.1 39.4 5.9
 11.HPV16/33/58+ or p16+ 1406 51.5 132/53 10.7/26.5 49.1 2.9
 12.HPV16/33/58/31+ or p16+ 1522 55.7 132/53 11.5/28.7 53.6 2.9
 13.HPV16/33/58/31/35+ or p16+ 1570 57.5 132/53 11.9/29.6 55.4 2.9
 14.HPV16/18+ or p16+ 1219 44.6 129/53 9.4/23.0 42.0 5.1
 15.HPV16/18/31/33/45/52/58+ or p16+ 2007 73.5 133/53 15.1/37.9 72.2 2.2
HPV types + & p16+
 16.HPV16+ or HPV33/58/31/35 + &p16+ 780 28.6 108/49 7.2/15.9 25.9 20.6
 17.HPV16/33+ or HPV58/31/35 + &p16+ 881 32.3 109/49 8.1/18.0 29.7 19.9
 18.HPV16/33/58/31/35 + &p16+ 429 15.7 94/39 4.6/11.0 12.9 30.9
 19.HPV16/18/31/33/45/52/58 + &p16+ 576 21.1 105/41 5.5/14.0 18.2 22.8
  1. CRR Colposcopy referral rate, NRND The number of referrals needed to detect one case, FPR False positive rate = 1-specificity, proportion of index test positives among histologic normal results (cervical intraepithelial neoplasia grade 1 or less), FNR False negative rate = 1-sensitivity, proportion of index test negatives among histologic abnormal results (CIN2+)