Table 5 Summary of Findings comparison 1
From: Self-management interventions for adolescents living with HIV: a systematic review
Summary of findings: Self-management interventions compared to control in adolescents living with HIV | |||||
|---|---|---|---|---|---|
Patient or population: Adolescents living with HIV; Setting: Low-, middle-, and high-income countries; Intervention: Self-management interventions with 1–2 components; Comparison: Usual care | |||||
Outcome | Follow-up | Pooled effect (95%CI) | No. of participants (studies) | Certainty of evidence (GRADE) | Comments |
Confidence | 3 months | MD 0.35 (0.01 to 0.69) | 33 (1 trial) | ⨁◯◯◯ VERY LOW a,b,c | HIV self-management interventions compared to usual care for adolescents living with HIV may increase confidence at 3-month follow-up and may make little or no difference to confidence at 4-, 6-, 9- and 12-month follow-ups, but the evidence is very uncertain. |
4 months | MD 0.00 (−0.26 to 0.26) | 96 (1 trial) | |||
MD 0.35 (−2.12 to 2.82) | 61 (1 trial) | ||||
6 months | MD 0.14 (−0.32 to 0.60) | 31 (1 trial) | |||
9 months | MD 0.10 (−0.17 to 0.37) | 91 (1 trial) | |||
12 months | MD 0.21 (−0.22 to 0.64) | 31 (1 trial) | |||
Adherence (self-reported) | 3 months | SMD 0.19 (−0.09 to 0.48) | 198 (3 trials) | ⨁◯◯◯ VERY LOW a,b,c | HIV self-management interventions compared to usual care for adolescents living with HIV may make little or no difference to self-reported adherence at 3-, 6- and 9-month follow-ups, and may increase adherence at 12-month follow-up, but the evidence is very uncertain. |
6 months | SMD 0.71 (−0.02 to 1.44) | 31 (1 trial) | |||
9 months | SMD 0.11 (−0.30 to 0.52) | 91 (1 RCT) | |||
12 months | SMD 1.16 (0.39 to 1.93) | 31 (1 trial) | |||
Adherence (Electronic pill monitoring) | 4 months | SMD 0.29 (− 0.21 to 0.8) | 61 (1 trial) | ⨁◯◯◯ VERY LOW a,b,c | HIV self-management interventions compared to usual care for adolescents living with HIV may make little or no difference to adherence at 4-month follow-up, but the evidence is very uncertain. |
Sexual risk behaviour | 4 months | MD 0.4 (−0.76 to 1.56) | 96 (1 trial) | ⨁◯◯◯ VERY LOW a,b,c | HIV self-management interventions compared to usual care for adolescents living with HIV may make little or no difference to sexual risk behaviour at 4- and 9-month follow-ups, but the evidence is very uncertain. |
9 months | MD −0.90 (−2.39 to 0.59) | 91 (1 trial) | |||
Viral load (log 10) | 4 months | MD −0.12 (− 0.45 to 0.2) | 157 (2 trials) | ⨁⨁◯◯ LOW a,b | HIV self-management interventions compared to usual care for adolescents living with HIV may make little or no difference to viral load at 4- and 9-month follow-ups. At 6- and 12-month follow-ups, HIV self-management interventions compared to usual care may decrease viral load, but the evidence is very uncertain. |
6 months | MD −1.70 (−2.65 to − 0.75) | 30 (1 trial) | ⨁◯◯◯ VERY LOW a,b,c | ||
9 months | MD −0.02 (− 0.30 to 0.26) | 237 (2 trials) | ⨁⨁◯◯ LOW a,b | ||
12 months | MD −1.00 (− 1.89 to −0.11) | 31 (1 trial) | ⨁◯◯◯ VERY LOW a,b,c | ||
Depression | 3 months | SMD −0.27 (− 0.56 to 0.01) | 194 (3 trials) | ⨁◯◯◯ VERY LOW a,b,c | HIV self-management interventions compared to usual care for adolescents living with HIV may make little or no difference to depression at 3-, 6-, 9- and 12-month follow-ups, but the evidence is very uncertain. |
6 months | SMD −0.57 (−1.29 to 0.15) | 31 (1 trial) | |||
9 months | SMD −0.12 (− 0.48 to 0.25) | 117 (2 trials) | |||
12 months | SMD −0.26 (− 0.97 to 0.45) | 31 (1 trial) | |||