Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis

Cong, Shan; Ma, Tiangang; Di, Xin; Tian, Chang; Zhao, Min; Wang, Ke

doi:10.1186/s12879-021-06064-0

BMC Infectious Diseases

Table 1 Baseline characteristics of included studies in the meta analysis

From: Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis

first author	publication time	country	study design	diagnostic criteria	clinical setting	biomarker	sample size	TP	FP	FN	TN	SEN (%)	SPE (%)	average age	test method
Anand [23]a	2015	India	PS	culture+	ICU	PCT	118	68	6	4	40	94.4	87	49.3	IF
Anand [23]a						IL-6	118	46	5	26	41	63.9	89	49.3	ECLI
Anand [23] b	2015	India	PS	clinical,culture-	ICU	PCT	136	83	13	7	33	92.2	72	52.1	IF
Anand [23] b						IL-6	136	42	12	48	34	47	73	52.1	ECLI
Bauer [26]	2016	America	PS	clinical	ICU	CD64	196	84	20	26	66	76.4	76.7		FCM
Bauer [26]						PCT	216	88	25	32	71	73.1	74.2		IF
Cardelli [27]	2008	Italy	PS	clinical,culture+	ICU	CD64	112	50	5	2	55	96	91.7	63	FCM
Cardelli [27]						PCT	112	49	27	3	33	94	70	63	IF
Castelli [28]	2004	Italy	PS	clinical,culture+	ICU	PCT	49	21	2	13	13	61.7	86.7		IF
Cheval [29]	2000	France	PS	clinical	ICU	PCT	60	28	5	4	23	87.5	82.1	56.3	IF
Clec’h [25] a	2006	France	PS	clinical	SICU	PCT	67	28	9	3	27	91.7	74.2	63	IF
Clec’h [25] b	2006	France	PS	clinical	MICU	PCT	76	29	2	7	38	80.6	95	60.1	IF
Davis [30]	2006	America	RS	clinical,culture+	ED	CD64	100	33	18	5	44	86.8	71		FCM
Dimoula [31]	2014	Belgium	PS	clinical	ICU	CD64	468	92	47	11	318	89.3	87.1	58.7	FCM
Du [32]	2003	China	PS	clinical	ICU	PCT	51	16	8	4	23	80	74.2	64.7	IF
Du [32]						IL-6	51	17	8	3	23	85	74	64.7	EIA
Feng [33]	2012	China	PS	clinical	ICU	PCT	132	69	12	33	18	67.6	60		ELISA
Gaini [34]	2006	Denmark	PS	clinical	GW	PCT	93	56	9	18	10	75.7	52.6	63	IF
Gaini [34]						IL-6	93	60	4	14	15	81.1	78.9	63	ECLI
Gamez-Diaz [35]	2011	Colombia	PS	clinical	ED	CD64	610	266	73	138	133	65.8	65		Leuko64 kit
Gerrits [36]	2013	Netherla-nds	PS	clinical	ICU	CD64	44	25	1	0	18	100	94.7	71.8	Leuko64 kit
Gibot [37]	2012	France	PS	clinical	ICU	CD64	300	130	7	24	139	84.4	95.2	61.5	FCM
Gibot [37]						PCT	300	128	30	26	124	83.1	84.9	61.5	ECLI
Gros [38]	2012	France	PS	clinical, culture+	MICU	CD64	293	93	16	55	129	62.8	89	59.5	Leuko64 kit
Gupta [24] a	2018	India	PS	culture+		PCT	242	193	5	3	41	98.5	89.1		ECLI
Gupta [24] b	2018	India	PS	clinical,culture-		PCT	109	55	10	8	36	87.3	78.3		ECLI
Harbarth [39]	2001	Switzerla-nd	PS	clinical	ICU	PCT	78	58	4	2	14	97	78		ECLI
Harbarth [39]						IL-6	78	40	5	20	13	67	72		ECLI
Hausfater [40]	2002	France	PS	clinical	ED	PCT	195	42	15	26	112	61.8	88.2	47	IFA
Hsu [41]	2011	China	PS	clinical, culture+	RICU	CD64	66	49	1	6	10	89	90.9	68.3	FCM
Hsu [41]						PCT	66	31	0	24	11	56.4	100	68.3	IF
Ivancević [16]	2008	Serbia	PS	clinical,culture+	ED	PCT	98	42	15	16	25	72.4	62.5	54.7	IF
Jämsä [42]	2015	Finland	PS	clinical	ICU	CD64	42	27	1	0	14	100	93	64.4	FCM
Jekarl [43]	2012	Korea	PS	clinical	ED	PCT	177	58	13	20	86	74.4	86.7	51.5	ECLI
Jekarl [43]						IL-6	177	51	17	27	82	65.4	82.9	51.5	ECLI
Kofoed [44]	2007	Denmark	PS	clinical,culture+	ED/GW	PCT	151	77	23	19	32	80.2	58.2		ECLI
Latour-Pérez [45]	2010	Spain	PS	clinical	ICU	PCT	114	53	5	19	37	73.6	88.1		IF
Lewis [46]	2015	UK	RS	clinical, culture+	ICU	CD64	153	43	12	40	58	51.8	82.6		FCM
Mat-Nor [47]	2016	Malaysia	PS	clinical	ICU	PCT	239	93	20	71	55	57	73	47	IF
Mat-Nor [47]						IL-6	239	82	26	82	49	50	65	47	EI
Meynaar [48]	2011	Netherlands	PS	clinical,culture+	ICU	PCT	76	31	9	1	35	97	80		IF
Meynaar [48]						IL-6	76	29	26	3	18	91	41		ECLI
Mokart [18]	2005	France	PS	clinical	ICU	PCT	50	13	10	3	24	81	72		ECLI
Mokart [18]						IL-6	50	14	14	2	20	87.5	58.8		EIA
Muller [49]	2000	Switzerla-nd	PS	clinical	MICU	PCT	101	53	3	6	39	89.8	92.9		IFA
Muller [49]						IL-6	101	38	9	21	33	64.4	78.6		EIA
Muzlovic [17]	2016	Slovenia	PS	clinical,culture+	ICU	CD64	32	25	1	0	6	100	85.7	61.8	Leuko64 kit
Muzlovic [17]						PCT	32	21	0	4	7	81.8	100	61.8	IF
Papadimitriou [50]	2015	Greece	PS	clinical,culture+	ICU	CD64	66	24	3	5	34	83	92		FCM
Righi [51]	2014	Italy	PS	clinical,culture+	ICU	CD64	93	55	1	6	31	90.1	96.9	58.7	FCM
Ruokonen [52]	2002	Switzerla-nd	PS	clinical,culture+	ICU	PCT	208	110	24	52	22	67.9	47.8		IF
Selberg [53]	2000	Germany	PS	clinical,culture+	ICU	PCT	33	19	5	3	6	86	54	47.9	IF
Selberg [53]						IL-6	33	19	5	3	6	86.4	54.5	47.9	EIA
Shokouhi [22] a	2017	Iran	PS	culture+		PCT	192	76	18	16	82	82.6	82	43.9	ELISA
Shokouhi [22] b	2017	Iran	PS	culture+		PCT	184	58	30	26	70	69.1	70	73.1	ELISA
Spoto [54]	2018	Italy	PS	clinical, culture+	ICU/GW	PCT	159	60	1	49	49	55	98	70.5	IF
Suprin [55]	2000	France	PS	clinical. culture+	ICU	PCT	95	49	6	26	14	65.3	70	57	IF
Talebi-Taher [20]	2014	Iran	PS	clinical	ED	PCT	100	44	14	6	36	88.8	71.1	76.3	IF
Tan [56]	2016	Malaysia	PS	clinical,culture+	ED	CD64	51	34	1	8	8	80.9	88.9	53.7	FCM
Tromp [57]	2002	Netherla-nds	PS	culture+	ED	PCT	342	49	120	6	167	89.1	58.2		IF
Tromp [57]						IL-6	342	34	79	21	208	61.8	72.5		EI
Tsalik [58]	2012	America	PS	clinical,culture+	ED	PCT	336	168	33	79	56	68	62.9		ECLI
Tsalik [58]						IL-6	336	144	29	103	60	58.3	67.4		ECLI
Wang [59]	2013	China	RS	culture+	ICU	PCT	586	100	162	20	304	83.3	65.2		IF
Zhang [21]	2017	China	PS	clinical	ICU	PCT	70	36	6	14	14	72	70	92.6	ECLI
Huang [60]	2012	China	PS	clinical	ICU	PCT	72	40	3	9	20	82.3	84.9	66.2	ELISA
Lu [19]	2016	China	PS	clinical	ICU	CD64	420	111	35	19	255	85.1	87.8		FCM
Shao [61]	2014	China	PS	clinical	ICU/RD	CD64	87	63	4	6	14	91.3	77.8	54	FCM
Tang [62]	2017	China	PS	clinical	ICU	PCT	221	74	24	15	108	83.2	82.1	51.6	ECLI
Tang [62]				clinical	ICU	IL-6	221	67	77	22	55	75.3	41.2	51.6	ECLI
Wang [63]	2017	China	PS	clinical	MD	CD64	44	23	1	6	14	79.5	93.3	47.1	FCM
Xing [64]	2008	China	PS	clinical	ED/GW/ICU	PCT	149	84	6	8	51	91.3	89.5	67.3	IF
Xu [65]	2009	China	PS	clinical	ICU/HD	CD64	68	57	1	1	9	98.3	90		FCM
Zhang [66]	2012	China	PS	clinical		CD64	55	30	5	5	15	85.7	75	50.6	FCM
Zhao [67]	2017	China	PS	clinical	ICU	PCT	104	67	5	11	21	85.9	81.8	57.9	IF
Zhao [68]	2016	China	RS	clinical	ED	PCT	393	255	10	52	76	83.2	88.1	42	ECLI
Zhao [68]						IL-6	393	249	14	58	72	81.1	83.7	42	EIA
Zhao [69]	2014	China	PS	clinical	ED	PCT	652	340	40	112	160	75.2	80	72	ELISA
Zhao [69]						IL-6	652	366	78	86	122	81	61	72	EIA

PS Prospective Study, RS Retrospective Study, ICU intensive care unit, SICU Surgical intensive care unit, MICU Medical Intensive Care Unit, RICU Respiratory intensive care unit, ED Emergency Department, GW General ward, RD Respiratory Department, HD Hematology Department, IF Immunofluorescence, FCM flow cytometer, ECLI Electrochemical immunoluminescence, EIA enzyme imrrmnoassay, ELISA enzyme linked immunosorbent assay

Back to article page

ISSN: 1471-2334

Contact us

Submission enquiries: bmcinfectiousdiseases@biomedcentral.com
General enquiries: ORSupport@springernature.com