Table 5 Characteristics of patients with rheumatic diseases and pneumonia caused by K. pneumoniae with or without ESBL production
Variables | ESBL-positive (N = 23) | ESBL-negative (N = 32) | p value |
|---|---|---|---|
Age (years) | 48.0 ± 14.6 | 54.2 ± 18.0 | 0.096 |
Sex (female) | 14 (60.9%) | 17 (53.1%) | 0.568 |
Duration of corticotherapy (months) | 17.5 ± 37.0 | 29.3 ± 54.2 | 0.444 |
Dose of corticosteroids (mg) | 72.3 ± 53.3 | 37.6 ± 28.4 | 0.015 |
Hospitalization within last 90 days | 20 (87.0%) | 23 (71.9%) | 0.182 |
Previous antimicrobial therapy within 30 days | 22 (95.7%) | 25 (78.1%) | 0.120 |
Diabetes mellitus | 5 (21.7%) | 9 (28.1%) | 0.592 |
Fever | 19 (82.6%) | 23 (71.9%) | 0.355 |
Cough/expectoration | 18 (78.3%) | 27 (84.4%) | 0.726 |
Respiratory failure at admission | 10 (43.5%) | 14 (43.8%) | 0.984 |
Blood leukocyte count (109/L) | 0.035 | ||
< 4 | 3 (13.0%) | 4 (12.5%) | |
4–10 | 14 (60.9%) | 9 (28.1%) | |
> 10 | 6 (26.1%) | 19 (59.4%) | |
Blood neutrophil count (109/L) | 8.17 ± 5.99 | 9.13 ± 5.03 | 0.246 |
Blood lymphocyte count (/μL) | 516 ± 291 | 1143 ± 1255 | 0.015 |
Albumin (g/L) | 28.9 ± 4.8 | 30.2 ± 4.9 | 0.259 |
Urea (mmol/L) | 9.71 ± 5.61 | 8.99 ± 7.37 | 0.187 |
C-reactive protein (mg/L) | 66.0 ± 59.8 | 79.0 ± 69.7 | 0.703 |
PCT (ng/ml) | 0.899 | ||
< 0.5 | 15 (65.2%) | 20 (62.5%) | |
0.5–2 | 3 (13.0%) | 6 (18.8%) | |
2–10 | 4 (17.4%) | 4 (12.5%) | |
> 10 | 1 (4.4%) | 2 (6.2%) | |
CMV viremia | 12 (52.2%) | 6 (18.8%) | 0.009 |