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Table 3 Estimated clinical diagnostic parameters of the COVID-19 IB assays

From: IgG and IgM antibody formation to spike and nucleocapsid proteins in COVID-19 characterized by multiplex immunoblot assays

  Estimated 95% Confidence Interval
Value Lower Limit Upper Limit
IgM antibodies only
Sensitivity 0.7027 0.5283 0.8356
Specificity 0.9913 0.9657 0.9985
PPV 0.9286 0.7504 0.9875
NPV 0.9542 0.9172 0.9757
IgG antibodies only
Sensitivity 0.9189 0.7698 0.9788
Specificity 0.9913 0.9657 0.9985
PPV 0.9444 0.7999 0.9903
NPV 0.9871 0.9596 0.9967
IgG and/or IgM antibodies
Sensitivity 0.9723 0.8419 0.9986
Specificity 0.9827 0.9533 0.9944
PPV 0.9000 0.7540 0.9675
NPV 0.9956 0.9720 0.9998
  1. PPV positive predictive vale; NPV negative predictive value