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Table 5 Adverse drug reactions of artemisinin combination therapies among P. falciparum patients (9 studies included)

From: Efficacy and safety of artemisinin-based combination therapies for the treatment of uncomplicated malaria in pediatrics: a systematic review and meta-analysis

No. Drug used in the study Number of studies mentioned ADRs as drug related Frequency (%) of patients with ADRs relevant to specific treatment regimen
1 Artemether–Lumefantrine (AL) 5 88/1263 (6.9%)
2 Artesunate–Amodiaquine (AS+AQ) 5 69/1574 (4.4%)
3 Dihydroartemisinin–Piperaquine (DP) 2 5/273 (1.8%)
4 Artesunate-Sulphamethoxypyrazine-Pyrimethamine (AS+SMP) 1 3/250 (1.2%)
5 Pyronaridine:artesunate (PA) (tab & granule) 1 7/30 (23.3%)
6 Chlorproguanil-dapsone-artesunate (CDA) 1 184/914 (20.1%)
  Total   356/4304 (8.3%)