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Table 2 Univariate and multivariate analyses showing significant predictive factors of acute kidney injury (n = 1252)

From: Impact of acute kidney injury on survival in patients with chronic hepatitis C: a retrospective cohort study

Variable

Univariate analysis

Multivariate analysis

P

HR (95% CI)

P

HR (95% CI)

Male

0.022

1.32 (1.04–1.68)

0.057

1.28 (0.99–1.64)

Age per year

< 0.001

1.03 (1.02–1.04)

0.041

1.01 (1.00–1.02)

Hypertension

< 0.001

1.58 (1.24–2.00)

0.003

1.49 (1.14–1.94)

Diabetes

< 0.001

1.97 (1.55–2.51)

0.041

1.31 (1.01–1.69)

Platelet per 109/L

< 0.001

0.99 (0.99–1.00)

0.348

0.99 (0.99–1.01)

MELD score per point

< 0.001

1.15 (1.13–1.18)

0.035

1.06 (1.00–1.11)

Child-Pugh score per point

< 0.001

1.72 (1.59–1.86)

< 0.001

1.26 (1.09–1.46)

SVR

< 0.001

0.21 (0.16–0.29)

< 0.001

0.31 (0.23–0.43)

Extrahepatic malignancy

0.002

1.73 (1.22–2.47)

0.009

1.65 (1.13–2.41)

CH (diagnosis at entry)

Reference

Reference

 Com-LC

0.001

1.83 (1.26–2.65)

0.102

1.40 (0.94–2.09)

 Decom-LC or HCC

< 0.001

5.49 (4.10–7.35)

< 0.001

2.47 (1.72–3.57)

  1. Abbreviations: HR Hazard ratio, CI Confidence interval, MELD score Model for end-stage liver disease score, SVR Sustained virologic response, Com-LC Compensated cirrhosis, Decom-LC Decompensated cirrhosis, HCC Hepatocellular carcinoma